Inhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegans

Publication Overview
TitleInhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegans
AuthorsPeng H, Wei Z, Luo H, Yang Y, Wu Z, Gan L, Yang X
TypeJournal Article
Journal NameJournal of agricultural and food chemistry
Year2016
CitationPeng H, Wei Z, Luo H, Yang Y, Wu Z, Gan L, Yang X. Inhibition of Fat Accumulation by Hesperidin in Caenorhabditis elegans. Journal of agricultural and food chemistry. 2016 Jun 7.

Abstract

Hesperidin, abundant in citrus fruits, has a wide range of pharmacological effects including anticarcinogenic, anti-inflammatory, antioxidative, radioprotective and antiviral activities. However, relatively few studies on the effects of hesperidin on lipid metabolism have been reported. Here, using Caenorhaditis elegans as a model animal, we found that 100 µM hesperidin significantly decreased fat accumulation both in high fat worms cultured in nematode growth medium containing 10 mM glucose (83.5%±1.2 vs control by Sudan black B staining and 87.6%±2.0 vs control by Oil Red O staining, P<0.001) and daf-2 mutant worms (87.8%±1.4 vs control by Oil Red O staining, P<0.001). Furthermore, 50 µM hesperidin decreased the ratio of oleic acid to stearic acid (C18:1Δ9/C18:0) (P<0.05), and supplementation of oleic acid could restore the inhibitory effect of hesperidin on fat accumulation. Hesperidin significantly downregulated the expression of stearoyl-CoA desaturase, fat-6 and fat-7 (P<0.05), and mutation of fat-6 and fat-7 reversed fat accumulation inhibited by hesperidin. In addition, hesperidin decreased the expression of other genes involved in lipid metabolism, including pod-2, mdt-15, acs-2 and kat-1 (P<0.05). These results suggested that hesperidin reduced fat accumulation by affecting several lipid metabolism pathways, such as fat-6 and fat-7. This study provided new insights into elucidating the mechanism underlying the regulation of lipid metabolism by hesperidin.

Features
This publication contains information about 1 features:
Feature NameUniquenameType
Bf0116Bf0116genetic_marker
Properties
Additional details for this publication include:
Property NameValue
Publication ModelPrint-Electronic
ISSN1520-5118
eISSN1520-5118
Publication Date2016 Jun 7
Journal AbbreviationJ. Agric. Food Chem.
LanguageEnglish
Language AbbrENG
Publication TypeJournal Article
Cross References
This publication is also available in the following databases:
DatabaseAccession
PMID: PubMedPMID:27267939