Aqueous Extraction of Citrus unshiu Peel Induces Proangiogenic Effects Through the FAK and ERK1/2 Signaling Pathway in Human Umbilical Vein Endothelial Cells

Publication Overview
TitleAqueous Extraction of Citrus unshiu Peel Induces Proangiogenic Effects Through the FAK and ERK1/2 Signaling Pathway in Human Umbilical Vein Endothelial Cells
AuthorsLee J, Yang DS, Han SI, Yun JH, Kim IW, Kim SJ, Kim JH
TypeJournal Article
Journal NameJournal of medicinal food
Volume19
Issue6
Year2016
Page(s)569-77
CitationLee J, Yang DS, Han SI, Yun JH, Kim IW, Kim SJ, Kim JH. Aqueous Extraction of Citrus unshiu Peel Induces Proangiogenic Effects Through the FAK and ERK1/2 Signaling Pathway in Human Umbilical Vein Endothelial Cells. Journal of medicinal food. 2016 Jun; 19(6):569-77.

Abstract

Citrus unshiu peel has been used empirically as a traditional medicine to improve bronchial asthma and blood circulation in northeast Asian nations, including Korea, Japan, and China. In this study, we report the proangiogenic effects of the aqueous extract of Citrus unshiu peel (AECUP). In human umbilical vein endothelial cells, AECUP significantly induced cellular migration and capillary tube formation. We also demonstrated that AECUP markedly increased the phosphorylation of FAK and ERK1/2 through the integrin signaling pathway. Additionally, we identified that narirutin and hesperidin were major constituents of AECUP and both showed proangiogenic effects, but at different levels. Collectively, these results suggest that the AECUP may have potential as a therapeutic agent for improving angiogenic functions with reduced harmful side effects.

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Properties
Additional details for this publication include:
Property NameValue
Publication ModelPrint
ISSN1557-7600
eISSN1557-7600
Publication Date2016 Jun
Journal AbbreviationJ Med Food
DOI10.1089/jmf.2015.3584
Elocation10.1089/jmf.2015.3584
LanguageEnglish
Language Abbreng
Publication TypeJournal Article
Journal CountryUnited States