HrpG regulates type II secretory proteins in Xanthomonas axonopodis pv. citri

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TitleHrpG regulates type II secretory proteins in Xanthomonas axonopodis pv. citri
AuthorsYamazaki A, Hirata H, Tsuyumu S
TypeJournal Article
Journal NameJournal of general plant pathology
CitationYamazaki A, Hirata H, Tsuyumu S. HrpG regulates type II secretory proteins in Xanthomonas axonopodis pv. citri. Journal of general plant pathology. 2008; 74(2):138-150.


HrpG, a two-component response regulator-like protein, is a key regulator of the type III secretion system (T3SS) in Xanthomonas spp. In X. campestris pv. vesicatoria, HrpG with a single amino acid substitution (HrpG*) gains the ability to induce the expression of T3SS-related genes even under nutrient-rich conditions. In this study, we investigated the role of HrpG in the synthesis of the secretory protein using HrpG* in strain NA-1 of X. axonopodis pv. citri (Xac NA-1), a causal agent of citrus canker. Eleven proteins secreted via a type II secretion system (T2SS) were induced by HrpG*. In proteomic analyses, six of the 11 proteins were identified as extracellular enzymes, and the others as a fimbrial biogenesis-related protein, a type IV-related protein, two hypothetical proteins, and a conserved hypothetical protein. Further analysis of these proteins revealed that the genes coding all 11 proteins were upregulated by HrpG*, even though they had different expression patterns for HrpXct-dependency. The data indicated that HrpG, a key regulator of T3SS, also acts as a positive regulator of certain proteins secreted via a T2SS in Xac NA-1.
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Publication TypeJournal Article
Publication Date2008
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Language Abbreng
Publication Model[electronic resource].
KeywordsCitrus, Xanthomonas axonopodis pv. citri, amino acid substitution, enzymes, gene expression regulation, genes, protein secretion, proteomics, type II secretion system, type III secretion system
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AGL: USDA National Agricultural LibraryAGL:4037152