CF417199

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDK9_BOVIN (Cell division protein kinase 9 OS=Bos taurus GN=CDK9 PE=2 SV=1)

HSP 1 Score: 106.301 bits (264), Expect = 8.870e-28
Identity = 70/200 (35.00%), Postives = 104/200 (52.00%), Query Frame = 3

Query:   12 KYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKS----YTHEIVTLWYR 599
            KYEKL K+G+GT+G+V+KAK + TGQ VALKK  +E ++EG P TALRE+ +LQ+L     VV L+ +    +S                 N  K ++YLVF++ + DL   + +            + I+  +  L  G+ + H + +LHRD+K  N               GL RAF++   S    YT+ +VTLWYR
Sbjct:   18 KYEKLAKIGQGTFGEVFKAKHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE-NVVNLIEICRTKAS---------------PYNRCKGSIYLVFDFCEHDLAGLLSNVLV-----KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN-VLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195          

HSP 2 Score: 37.7354 bits (86), Expect = 8.870e-28
Identity = 15/29 (51.72%), Postives = 18/29 (62.07%), Query Frame = 1

Query:  604 PEVLLGSTHYSTAVDMWSVGCIFAEMVKR 690
            PE+LLG   Y   +D+W  GCI AEM  R
Sbjct:  197 PELLLGERDYGPPIDLWGAGCIMAEMWTR 225          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDK8_DICDI (Probable cyclin-dependent kinase 8 OS=Dictyostelium discoideum GN=cdk8 PE=2 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 1.503e-27
Identity = 71/203 (34.98%), Postives = 94/203 (46.31%), Query Frame = 3

Query:    9 EKYEKLEKVGEGTYGKVYKAKDKAT-GQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQN---XXXXXXXXXXXXXXXGLGRAFTVPLKSYTHE--IVTLWYR 599
            EKY    ++G GTYG VYKA DK      VA+KK R   + EG+  TA RE+ LL+ LS    +V+LL V                       N     LYL+F+Y + DL   I  HR+  N        I+S ++Q+  G+ + HS+ V+HRDLKP N                  GL R F  PLK       +VT+WYR
Sbjct:   42 EKYTFSYEIGSGTYGMVYKADDKKRPNNKVAVKKFRSTKEGEGLSLTAYREIGLLKELSNE-NIVKLLDV---------------------CLNPKDKLLYLIFDYAEFDLFGIIKYHRE--NGSHFSDATIKSLIWQVLNGIHYLHSNWVIHRDLKPSNILVMGEGKECGTVKIGDFGLARIFQSPLKPLNENGVVVTIWYR 220          

HSP 2 Score: 48.9062 bits (115), Expect = 1.503e-27
Identity = 18/28 (64.29%), Postives = 26/28 (92.86%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMV 684
            +PE+LLGS HY+ AVD+W++GCIFAE++
Sbjct:  221 SPELLLGSKHYTRAVDIWAIGCIFAELI 248          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDK9_HUMAN (Cell division protein kinase 9 OS=Homo sapiens GN=CDK9 PE=1 SV=3)

HSP 1 Score: 105.531 bits (262), Expect = 1.503e-27
Identity = 69/202 (34.16%), Postives = 105/202 (51.98%), Query Frame = 3

Query:    6 MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKS----YTHEIVTLWYR 599
            + KYEKL K+G+GT+G+V+KA+ + TGQ VALKK  +E ++EG P TALRE+ +LQ+L     VV L+ +    +S                 N  K ++YLVF++ + DL   + +            + I+  +  L  G+ + H + +LHRD+K  N               GL RAF++   S    YT+ +VTLWYR
Sbjct:   16 VSKYEKLAKIGQGTFGEVFKARHRKTGQKVALKKVLMENEKEGFPITALREIKILQLLKHE-NVVNLIEICRTKAS---------------PYNRCKGSIYLVFDFCEHDLAGLLSNVLV-----KFTLSEIKRVMQMLLNGLYYIHRNKILHRDMKAAN-VLITRDGVLKLADFGLARAFSLAKNSQPNRYTNRVVTLWYR 195          

HSP 2 Score: 37.7354 bits (86), Expect = 1.503e-27
Identity = 15/29 (51.72%), Postives = 18/29 (62.07%), Query Frame = 1

Query:  604 PEVLLGSTHYSTAVDMWSVGCIFAEMVKR 690
            PE+LLG   Y   +D+W  GCI AEM  R
Sbjct:  197 PELLLGERDYGPPIDLWGAGCIMAEMWTR 225          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDK11_DICDI (PITSVRE serine/threonine protein-kinase cdk11 OS=Dictyostelium discoideum GN=cdk11 PE=3 SV=1)

HSP 1 Score: 96.6709 bits (239), Expect = 2.549e-27
Identity = 59/197 (29.95%), Postives = 101/197 (51.27%), Query Frame = 3

Query:   15 YEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQS--LYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKSYTHEIVTLWYR 599
            ++KL  + EG +G VY A+DK T ++VALKK ++E + EGIP T++RE+ +L  L     + +  ++  ++++S                        +++  E++D DL+  ++  +K     P  P+ I++ + QL  GV++ H + V+HRDLK  N               GL R +  PLK  +  +VTLWYR
Sbjct:   52 FKKLYTINEGAFGVVYCAQDKETEEIVALKKIKMEREREGIPITSVREIKVLMELKHDNIVQIKEIVLGKNINS------------------------IFMAMEFIDHDLRGLMEVIKK-----PFLPSEIKTLIQQLLNGVSYMHDNWVIHRDLKTAN-LLYTNKGVLKIADFGLAREYGSPLKPLSKGVVTLWYR 218          

HSP 2 Score: 45.8246 bits (107), Expect = 2.549e-27
Identity = 18/32 (56.25%), Postives = 27/32 (84.38%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMVKRQV 696
            APE+LL +  Y+ A+D+WSVGCIFAE++ ++V
Sbjct:  219 APELLLDTEIYTPAIDIWSVGCIFAEIISKEV 250          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: BUR1_NEUCR (Serine/threonine-protein kinase bur-1 OS=Neurospora crassa GN=bur-1 PE=3 SV=1)

HSP 1 Score: 98.2117 bits (243), Expect = 5.584e-27
Identity = 69/212 (32.55%), Postives = 107/212 (50.47%), Query Frame = 3

Query:    3 RMEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRL--LCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPL-----------KSYTHEIVTLWYR 599
            R+  YE L K+GEGT+G+V++A+ + TG LVALKK  +  + +G P TALRE+ LL++LS    V+RL  + +EH   + K   P                 +Y+V  Y+D DL   +D+    P+ R   P  ++ +L QL +G+ + H++ +LHRD+K  N               GL R +   +           + YT  +VT WYR
Sbjct:   22 RIADYEVLGKLGEGTFGEVHRARSRKTGALVALKKIIMHNERDGFPITALREIKLLKLLSHK-NVLRLEEMAIEHPPRTDKRTRPI----------------VYMVTPYMDHDLSGLLDN----PSVRFTEPQ-VKCYLLQLLEGLKYLHANHILHRDMKAAN-LLINNKGVLQIADFGLARHYEGDIPQPGKGSGEGKRDYTSLVVTRWYR 210          

HSP 2 Score: 43.1282 bits (100), Expect = 5.584e-27
Identity = 16/28 (57.14%), Postives = 23/28 (82.14%), Query Frame = 1

Query:  604 PEVLLGSTHYSTAVDMWSVGCIFAEMVK 687
            PE+L+    Y+TA+DMW VGC+FAEM++
Sbjct:  212 PELLMHLKRYTTAIDMWGVGCVFAEMLE 239          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDKL4_MOUSE (Cyclin-dependent kinase-like 4 OS=Mus musculus GN=Cdkl4 PE=2 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 5.628e-27
Identity = 64/198 (32.32%), Postives = 96/198 (48.48%), Query Frame = 3

Query:    6 MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKSYTHEIVTLWYR 599
            MEKYEKL K+GEG+YG V+K ++K++GQ+VA+KK     D+  +   ALRE+ +L+ L     +V L+ V                          K  ++LVFEY D  L   ++      NP  +   +I+S L+Q  + +  CH H  +HRD+KP+N               G  R   +P  +YT  + T WYR
Sbjct:    1 MEKYEKLAKIGEGSYGVVFKCRNKSSGQVVAIKKFVESEDDRVVRKIALREIRMLKQLKHP-NLVNLIEVFR-----------------------RKRKMHLVFEYCDHTLLNELER-----NPNGVSDGVIKSVLWQTLQALNFCHKHNCIHRDVKPEN-ILITKQGMIKICDFGFAR-ILIPGDAYTDYVATRWYR 167          

HSP 2 Score: 45.4394 bits (106), Expect = 5.628e-27
Identity = 17/31 (54.84%), Postives = 26/31 (83.87%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMVKRQ 693
            APE+L+G T Y ++VD+W+VGC+FAE++  Q
Sbjct:  168 APELLVGDTKYGSSVDVWAVGCVFAELLTGQ 198          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDK4_XENLA (Cell division protein kinase 4 OS=Xenopus laevis GN=cdk4 PE=2 SV=1)

HSP 1 Score: 94.3597 bits (233), Expect = 5.636e-27
Identity = 66/198 (33.33%), Postives = 105/198 (53.03%), Query Frame = 3

Query:   12 KYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLY--VVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKSYTHEIVTLWYR 599
            +YE + ++G G YG VYKA+D  +G+ VALK  R++ +E G+P + +REV+LL+ L    +  +V+L+ V                ASA     + ++ + LVFE++D DLK ++    K P P  LP   I+  + Q   G+   H + ++HRDLKP+N               GL R ++  + + T  +VTLWYR
Sbjct:    8 QYEPVAEIGVGAYGTVYKARDLQSGKFVALKNVRVQTNENGLPLSTVREVTLLKRLEHFDHPNIVKLMDV---------------CASA---RTDRETKVTLVFEHVDQDLKTYLS---KVP-PPGLPLETIKDLMKQFLSGLEFLHLNCIVHRDLKPEN-ILVTSGGQVKLADFGLARIYSCQM-ALTPVVVTLWYR 181          

HSP 2 Score: 46.9802 bits (110), Expect = 5.636e-27
Identity = 23/31 (74.19%), Postives = 26/31 (83.87%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMVKRQ 693
            APEVLL ST Y+T VD+WS GCIFAEM KR+
Sbjct:  182 APEVLLQST-YATPVDVWSAGCIFAEMFKRK 211          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDKL2_MOUSE (Cyclin-dependent kinase-like 2 OS=Mus musculus GN=Cdkl2 PE=2 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 7.264e-27
Identity = 66/203 (32.51%), Postives = 95/203 (46.80%), Query Frame = 3

Query:    6 MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRL-LCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLD----TDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKSYTHEIVTLWYR 599
            MEKYE L  VGEG+YG V K ++K +G++VA+KK     D++ +   A+RE+ LL+ L     V  L +C +                         K   YLVFE++D     DLK F         P  L   ++Q +L+Q+  G+  CHSH ++HRD+KP+N               G  R    P + YT  + T WYR
Sbjct:    1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKK-------------------------KKRWYLVFEFVDHTILDDLKLF---------PNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN-ILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYR 168          

HSP 2 Score: 39.6614 bits (91), Expect = 7.264e-27
Identity = 15/31 (48.39%), Postives = 22/31 (70.97%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMVKRQ 693
            APE+L+G   Y  AVD+W++GC+  EM+  Q
Sbjct:  169 APELLVGDVKYGKAVDIWAIGCLVIEMLMGQ 199          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: CDKL2_RAT (Cyclin-dependent kinase-like 2 OS=Rattus norvegicus GN=Cdkl2 PE=2 SV=1)

HSP 1 Score: 101.293 bits (251), Expect = 7.277e-27
Identity = 66/203 (32.51%), Postives = 95/203 (46.80%), Query Frame = 3

Query:    6 MEKYEKLEKVGEGTYGKVYKAKDKATGQLVALKKTRLEMDEEGIPPTALREVSLLQMLSQSLYVVRL-LCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLD----TDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKSYTHEIVTLWYR 599
            MEKYE L  VGEG+YG V K ++K +G++VA+KK     D++ +   A+RE+ LL+ L     V  L +C +                         K   YLVFE++D     DLK F         P  L   ++Q +L+Q+  G+  CHSH ++HRD+KP+N               G  R    P + YT  + T WYR
Sbjct:    1 MEKYENLGLVGEGSYGMVMKCRNKDSGRIVAIKKFLESDDDKMVKKIAMREIKLLKQLRHENLVNLLEVCKK-------------------------KKRWYLVFEFVDHTILDDLKLF---------PNGLDYQVVQKYLFQIINGIGFCHSHNIIHRDIKPEN-ILVSQSGVVKLCDFGFARTLAAPGEVYTDYVATRWYR 168          

HSP 2 Score: 39.6614 bits (91), Expect = 7.277e-27
Identity = 15/31 (48.39%), Postives = 22/31 (70.97%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMVKRQ 693
            APE+L+G   Y  AVD+W++GC+  EM+  Q
Sbjct:  169 APELLVGDVKYGKAVDIWAIGCLVIEMLMGQ 199          

BLAST of CF417199 vs. ExPASy Swiss-Prot
Match: SSN3_YARLI (Serine/threonine-protein kinase SSN3 OS=Yarrowia lipolytica GN=SSN3 PE=3 SV=1)

HSP 1 Score: 90.5077 bits (223), Expect = 9.508e-27
Identity = 69/208 (33.17%), Postives = 105/208 (50.48%), Query Frame = 3

Query:    6 MEKYEKLEKVGEGTYGKVYKAKDKATGQL--VALKKTRLEMDEE-----GIPPTALREVSLLQMLSQSLYVVRLLCVEHVDSSLKSNNPSPDSASAFATSNNGKSNLYLVFEYLDTDLKKFIDSHRKGPNPRPLPPTLIQSFLYQLCKGVAHCHSHGVLHRDLKPQNXXXXXXXXXXXXXXXGLGRAFTVPLKS-YTHE--IVTLWYR 599
            ++KYE +  +  GTYG+VYKA+ K  G     A+KK + + + E     GI  +A REV+L   L     + +L     V++ L+                   + +Y+VFEY + DL + I  H   P  +P+P   ++S L+QL  GV++ H + VLHRDLKP N               GL R F+ PL+S Y+ +  +VT+WYR
Sbjct:   37 LDKYEIIGYIAAGTYGRVYKARSKDPGDTNQYAIKKFKADKEGEMVHYAGISQSACREVALCAELDNR-NITKL-----VETILED------------------TCIYMVFEYAEHDLLQIIHYHSH-PERKPIPEYTLKSILWQLLNGVSYLHQNWVLHRDLKPAN-TMVTSDGVLKIGDLGLARLFSNPLQSLYSGDKVVVTIWYR 218          

HSP 2 Score: 50.0618 bits (118), Expect = 9.508e-27
Identity = 20/28 (71.43%), Postives = 26/28 (92.86%), Query Frame = 1

Query:  601 APEVLLGSTHYSTAVDMWSVGCIFAEMV 684
            APE+LLG+ HYS AVD+W+VGCIFAE++
Sbjct:  219 APELLLGARHYSPAVDLWAVGCIFAELL 246