CK739758

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: M3K3_HUMAN (Mitogen-activated protein kinase kinase kinase 3 OS=Homo sapiens GN=MAP3K3 PE=1 SV=2)

HSP 1 Score: 81.6481 bits (200), Expect = 1.949e-21
Identity = 45/108 (41.67%), Postives = 66/108 (61.11%), Query Frame = 2

Query:   38 EVNLLVKLRHPNIVQFLGAVTER--KPLMLITEYLRGGDLHKYLKEKGALSPSTAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIK 355
            E+ LL  L+H  IVQ+ G + +R  K L +  EY+ GG +   LK  GAL+ S    +   I  GM+YLH+  N+I+HRD+K  N+L    SA ++K+GDFG SK ++
Sbjct:  412 EIQLLKNLQHERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS--NMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQ 515          

HSP 2 Score: 41.5874 bits (96), Expect = 1.949e-21
Identity = 21/52 (40.38%), Postives = 28/52 (53.85%), Query Frame = 1

Query:  382 MTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPLANYEPYEA 537
            M   TG+  +M+PEV     Y +K DV+S    + EML  +PP A YE   A
Sbjct:  524 MRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAA 575          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: DRKB_DICDI (Probable serine/threonine-protein kinase drkB OS=Dictyostelium discoideum GN=drkB PE=3 SV=1)

HSP 1 Score: 85.8853 bits (211), Expect = 2.531e-21
Identity = 45/112 (40.18%), Postives = 68/112 (60.71%), Query Frame = 2

Query:   17 VIQDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYL-KEKGALSPSTAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKL 349
            ++++F  E+NL+  LRHPN++QFLG+      + + TEY+  G L+  L  EK  +S S      +D A+G+ YLH    VI+HRDLK  N+L+  +    +KV DFGLS +
Sbjct:  429 ILKEFHREINLMKNLRHPNVIQFLGSCLISPDICICTEYMPRGSLYSILHNEKIKISWSLVKRMMIDAAKGIIYLHGSTPVILHRDLKSHNLLVDENW--KVKVADFGLSTI 538          

HSP 2 Score: 36.965 bits (84), Expect = 2.531e-21
Identity = 15/46 (32.61%), Postives = 28/46 (60.87%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPLANYEPYE 534
            G+  + +PEV + ++Y +K DV+SF +IL+E    + P     P++
Sbjct:  549 GTPCWTSPEVLRSQRYTEKADVYSFGIILWECATRQDPYFGIPPFQ 594          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: Y9955_DICDI (Probable serine/threonine-protein kinase DDB_G0267514 OS=Dictyostelium discoideum GN=DDB_G0267514 PE=3 SV=1)

HSP 1 Score: 80.1073 bits (196), Expect = 3.276e-21
Identity = 49/112 (43.75%), Postives = 69/112 (61.61%), Query Frame = 2

Query:   17 VIQDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYL-KEKGALSPSTAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKL 349
            V+++FR E+ +L +LRHPNIV  + A T    L  ITEYL GG L+  L  +K  ++       A+ IA+GM YLH   + +IHRD+K  N+LL      ++K+ DFGLSKL
Sbjct:  701 VLEEFRKELTILSRLRHPNIVLLMAACTAPPNLCFITEYLPGGSLYDALHSKKIKMNMQLYKKLAIQIAQGMNYLH--LSGVIHRDIKSLNLLL--DEHMNVKICDFGLSKL 808          

HSP 2 Score: 42.3578 bits (98), Expect = 3.276e-21
Identity = 20/54 (37.04%), Postives = 33/54 (61.11%), Query Frame = 1

Query:  379 QMTGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPLANYEPYEAA 540
            +MT   GS  +M+PE+     Y +KVDV++F +IL+E+  GE P +  +  + A
Sbjct:  814 EMTKSIGSPIWMSPELLMGEDYTEKVDVYAFGIILWELGTGELPYSGLDSVQLA 867          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: M3K3_MOUSE (Mitogen-activated protein kinase kinase kinase 3 OS=Mus musculus GN=Map3k3 PE=1 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 3.298e-21
Identity = 45/108 (41.67%), Postives = 66/108 (61.11%), Query Frame = 2

Query:   38 EVNLLVKLRHPNIVQFLGAVTER--KPLMLITEYLRGGDLHKYLKEKGALSPSTAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIK 355
            E+ LL  L+H  IVQ+ G + +R  K L +  EY+ GG +   LK  GAL+ S    +   I  GM+YLH+  N+I+HRD+K  N+L    SA ++K+GDFG SK ++
Sbjct:  412 EIQLLKNLQHERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYLHS--NMIVHRDIKGANIL--RDSAGNVKLGDFGASKRLQ 515          

HSP 2 Score: 41.5874 bits (96), Expect = 3.298e-21
Identity = 23/58 (39.66%), Postives = 31/58 (53.45%), Query Frame = 1

Query:  373 CVQMTG---ETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPLANYEPYEA 537
            C+  TG    TG+  +M+PEV     Y +K DV+S    + EML  +PP A YE   A
Sbjct:  518 CMSGTGIRSVTGTPYWMSPEVISGEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAA 575          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: RPK1_ARATH (Probable LRR receptor-like serine/threonine-protein kinase RPK1 OS=Arabidopsis thaliana GN=RPK1 PE=1 SV=1)

HSP 1 Score: 87.4261 bits (215), Expect = 7.279e-21
Identity = 48/119 (40.34%), Postives = 70/119 (58.82%), Query Frame = 2

Query:   23 QDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKE--KGALSPSTAVNFALDIARGMAYLHNEPN-VIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLIKGQNSH 370
            Q F  E++ L  +RHPN+V  +G       + LI  YL GG+L  ++KE  K A+        ALD+AR ++YLH + +  ++HRD+KP N+LL N+   +L   DFGLSKL+    SH
Sbjct:  300 QQFHAEISALEMVRHPNLVMLIGYHASETEMFLIYNYLSGGNLQDFIKERSKAAIEWKVLHKIALDVARALSYLHEQCSPKVLHRDIKPSNILLDNNYNAYL--SDFGLSKLLGTSQSH 416          

HSP 2 Score: 33.8834 bits (76), Expect = 7.279e-21
Identity = 14/43 (32.56%), Postives = 26/43 (60.47%), Query Frame = 1

Query:  385 TGETGSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPPL 513
            TG  G++ Y+APE     +  +K DV+S+ ++L E++  +  L
Sbjct:  419 TGVAGTFGYVAPEYAMTCRVSEKADVYSYGIVLLELISDKRAL 461          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: M3KL4_HUMAN (Mitogen-activated protein kinase kinase kinase OS=Homo sapiens GN=MLK4 PE=1 SV=1)

HSP 1 Score: 78.9518 bits (193), Expect = 9.357e-21
Identity = 50/136 (36.76%), Postives = 69/136 (50.74%), Query Frame = 2

Query:    5 DDRLVIQDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKEKGA--------------LSPSTAVNFALDIARGMAYLHNEPNV-IIHRDLKPRNVLLVNSSADH-------LKVGDFGLSK 346
            D     +  R E  L   LRHPNI++  G   ++  L L+ E+ RGG L++ L    A              + P   VN+A+ IARGM YLH E  V I+HRDLK  N+LL+    +H       LK+ DFGL++
Sbjct:  160 DAAAAAESVRREARLFAMLRHPNIIELRGVCLQQPHLCLVLEFARGGALNRALAAANAAPDPRAPGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLL-EKIEHDDICNKTLKITDFGLAR 294          

HSP 2 Score: 41.9726 bits (97), Expect = 9.357e-21
Identity = 17/38 (44.74%), Postives = 27/38 (71.05%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPP 510
            G+Y +MAPEV K   + K  D++S+ ++L+E+L GE P
Sbjct:  306 GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVP 343          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: M3K10_XENLA (Mitogen-activated protein kinase kinase kinase 10 OS=Xenopus laevis GN=map3k10 PE=2 SV=1)

HSP 1 Score: 78.1814 bits (191), Expect = 1.218e-20
Identity = 46/121 (38.02%), Postives = 66/121 (54.55%), Query Frame = 2

Query:    5 DDRLVIQDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKEKGALSPSTAVNFALDIARGMAYLHNEPNV-IIHRDLKPRNVLLVNSSADH------LKVGDFGLSK 346
            D  +  ++ R E  +   L HPNI+   G   +   L L+ EY RGG LH+ L  K  +     VN+A+ IA+GM YLHNE  V IIHRDL   N+L++  + +       L + DFGL++
Sbjct:  154 DINVTAENVRQEAKIFCMLCHPNIIALTGVCLKPPHLCLVMEYARGGPLHRALAGK-KVPAHVLVNWAVQIAKGMTYLHNEAIVPIIHRDLGSSNILILEKAENDDLFNKTLNITDFGLAR 273          

HSP 2 Score: 42.3578 bits (98), Expect = 1.218e-20
Identity = 18/38 (47.37%), Postives = 27/38 (71.05%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPP 510
            G+Y +MAPEV +   + K  DV+SF ++L+E+L GE P
Sbjct:  285 GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVP 322          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: M3K11_HUMAN (Mitogen-activated protein kinase kinase kinase 11 OS=Homo sapiens GN=MAP3K11 PE=1 SV=1)

HSP 1 Score: 77.0258 bits (188), Expect = 1.221e-20
Identity = 48/121 (39.67%), Postives = 65/121 (53.72%), Query Frame = 2

Query:    5 DDRLVIQDFRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKEKGALSPSTAVNFALDIARGMAYLHNEPNV-IIHRDLKPRNVLLV----NSSADH--LKVGDFGLSK 346
            D  +  +  R E  L   L HPNI+       E   L L+ EY  GG L + L  +  + P   VN+A+ IARGM YLH E  V +IHRDLK  N+LL+    +   +H  LK+ DFGL++
Sbjct:  153 DISVTAESVRQEARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGR-RVPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR 272          

HSP 2 Score: 43.5134 bits (101), Expect = 1.221e-20
Identity = 19/38 (50.00%), Postives = 27/38 (71.05%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEMLEGEPP 510
            G+Y +MAPEV K   + K  DV+SF ++L+E+L GE P
Sbjct:  284 GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVP 321          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: LIMK1_CHICK (LIM domain kinase 1 OS=Gallus gallus GN=LIMK1 PE=1 SV=1)

HSP 1 Score: 80.8777 bits (198), Expect = 1.227e-20
Identity = 50/118 (42.37%), Postives = 71/118 (60.17%), Query Frame = 2

Query:   29 FRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKEKGALSP-STAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLI---KGQNSH 370
            F  EV ++  L HPN+++F+G + + K L  ITEY++GG L   +K   +  P S  V+FA DIA GMAYLH+    IIHRDL   N L+  + +  + V DFGL++L+   K Q  H
Sbjct:  388 FLKEVKVMRCLEHPNVLKFIGVLYKEKRLNFITEYIKGGTLRGLIKSMDSHYPWSQRVSFAKDIAAGMAYLHSMN--IIHRDLNSHNCLVRENKS--VVVADFGLARLMVDEKNQPEH 501          

HSP 2 Score: 39.6614 bits (91), Expect = 1.227e-20
Identity = 16/33 (48.48%), Postives = 25/33 (75.76%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEML 495
            G+  +MAPE+   R YD+KVD+FSF ++L E++
Sbjct:  518 GNPYWMAPEMINGRSYDEKVDIFSFGIVLCEII 550          

BLAST of CK739758 vs. ExPASy Swiss-Prot
Match: LIMK1_RAT (LIM domain kinase 1 OS=Rattus norvegicus GN=Limk1 PE=2 SV=1)

HSP 1 Score: 80.4925 bits (197), Expect = 1.227e-20
Identity = 50/116 (43.10%), Postives = 72/116 (62.07%), Query Frame = 2

Query:   29 FRHEVNLLVKLRHPNIVQFLGAVTERKPLMLITEYLRGGDLHKYLKEKGALSP-STAVNFALDIARGMAYLHNEPNVIIHRDLKPRNVLLVNSSADHLKVGDFGLSKLI---KGQN 364
            F  EV ++  L HPN+++F+G + + K L  ITEY++GG L   +K   +  P S  V+FA DIA GMAYLH+    IIHRDL   N L+  +   ++ V DFGL++L+   KGQ+
Sbjct:  381 FLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMN--IIHRDLNSHNCLVRENR--NVVVADFGLARLMIDEKGQS 492          

HSP 2 Score: 40.0466 bits (92), Expect = 1.227e-20
Identity = 17/33 (51.52%), Postives = 25/33 (75.76%), Query Frame = 1

Query:  397 GSYRYMAPEVFKHRKYDKKVDVFSFAMILYEML 495
            G+  +MAPE+   R YD+KVDVFSF ++L E++
Sbjct:  511 GNPYWMAPEMINGRSYDEKVDVFSFGIVLCEII 543