EY679879

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: IRE1_YEAST (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Saccharomyces cerevisiae GN=IRE1 PE=1 SV=2)

HSP 1 Score: 142.895 bits (359), Expect = 2.502e-33
Identity = 92/297 (30.98%), Postives = 139/297 (46.80%), Query Frame = 1

Query:    7 VRKLFVSNTEIAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAK-----------LSDMGISRRLLGDMSSLGHHATG-CGSSGWQAPEQLLHG-------------------------------RATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINIYK 768
            ++ L VS   +  GS+GTVV++G ++GRPVAVKR++    D+A  EI+ L  SD HPN++R+Y  E    F+Y++LE C  +L DL+++ + S        D+  +   EY                           +SL+R + SG+ HLH L IIHRDLKPQN+L+       A            +SD G+ ++L    SS   +     G+SGW+APE L                                  R TR+++  S  CV ++ +  G+HP GD+  R  NI +
Sbjct:  670 LKNLVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVS--------DENLKLQKEYN-------------------------PISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSGWRAPELLEESNNLQCQVETEHSSSRHTVVSSDSFYDPFTKRRLTRSIDIFSMGCVFYYILSKGKHPFGDKYSRESNIIR 933          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: PPK4_SCHPO (Serine/threonine-protein kinase ppk4 OS=Schizosaccharomyces pombe GN=ppk4 PE=2 SV=1)

HSP 1 Score: 138.272 bits (347), Expect = 6.162e-32
Identity = 94/281 (33.45%), Postives = 138/281 (49.11%), Query Frame = 1

Query:    7 VRKLFVSNTEIAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS-------LCAKLSDMGISRRLLGDMSSLGHHA-TGCGSSGWQAPEQLLHG-------------------RATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINIYK 768
            V  L V    I  GS+GT+VY G+YE R VAVKR++   +D+A +EI  L  SD HPNIVR+Y  +    F+Y+ +E C C+L DLI+                              K I  D  L+K     S  L+SL+  +  G+ HLH L ++HRDLKPQN+L++   S       + A +SD G+S++L  + SSL +      GS GW++PE +L G                   +A+ A +  +  C+ ++ + GG HP G   +   NI K
Sbjct:  650 VNSLTVYPEVIGYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLYIVIELCKCNLSDLIE------------------------------KPIAYD-DLFK-----SIDLVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKKLDFNQSSLRNTTFEAAGSYGWRSPE-ILSGSLSQQSKEIQVKTREGRIRQASHATDIFALGCIFYYTLTGGMHPFGSHYDCEGNILK 893          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: IRE1_CAEEL (Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=2 SV=2)

HSP 1 Score: 135.576 bits (340), Expect = 3.994e-31
Identity = 86/256 (33.59%), Postives = 127/256 (49.61%), Query Frame = 1

Query:   13 KLFVSNTEI-AKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLII---KERSLCAKLSDMGISRRLLGDMSSLGHH-ATG-CGSSGWQAPEQLLHGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINI 762
            KL  S ++I   G  GTVVY G ++GR VAVKR+V      A +E   L  SD HP+++R++ +E+D  F YL+LE C+ SL+D                       +E K    +V + +RD                +M+    GL HLH   I+HRD+KPQNVLI    +   + A +SD G+ +R+    +S+    A+G  G+ GW APE L+    +  V+  S  C+ ++ +  G HP G  L R  NI
Sbjct:  515 KLMYSPSDILGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIASLND----------------------YVEQKEVQQNVTIALRD----------------IMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKRVQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTHPFGKSLHRQANI 732          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: ERN2_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Mus musculus GN=Ern2 PE=2 SV=1)

HSP 1 Score: 134.42 bits (337), Expect = 8.897e-31
Identity = 84/247 (34.01%), Postives = 122/247 (49.39%), Query Frame = 1

Query:   37 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPE--QLLHGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINI 762
            + +G+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E+   F Y++LE C  SL + +++                                  DL  W     P+ +L  +M    SGL HLH L I+HRDLKP N+L+    S       +SD G+ ++L     S   H+   G+ GW APE  QL     T AV+  S  CV ++ + GG HP G+ L R  NI
Sbjct:  514 LGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVES---------------------------------PDLDRWGL--EPTTVLQQMM----SGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSLHSGIPGTEGWMAPELLQLPPDSPTNAVDIFSAGCVFYYVLSGGSHPFGESLYRQANI 721          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: ERN2_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=2)

HSP 1 Score: 132.88 bits (333), Expect = 2.589e-30
Identity = 85/248 (34.27%), Postives = 122/248 (49.19%), Query Frame = 1

Query:   37 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPE--QLL-HGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINI 762
            + +G+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E    F Y++LE C  SL + ++                 R  +E ++                           +++ L+SGL HLH L I+HRDLKP N+LI    S       LSD G+ ++L     S   H+   G+ GW APE  QLL     T AV+  S  CV ++ + GG HP GD L R  NI
Sbjct:  526 LGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVE------------NPDLDRGGLEPEV---------------------------VLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSLHSGIPGTEGWMAPELLQLLPPDSPTSAVDIFSAGCVFYYVLSGGSHPFGDSLYRQANI 734          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: IRLD_DICDI (Probable serine/threonine-protein kinase irlD OS=Dictyostelium discoideum GN=irlD PE=3 SV=1)

HSP 1 Score: 132.494 bits (332), Expect = 3.381e-30
Identity = 90/255 (35.29%), Postives = 136/255 (53.33%), Query Frame = 1

Query:   37 IAKGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIA--SDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSD----SSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINIY-KKPI 777
            I +GSNGT+V++GI+  R PVA+K++ +A + +  KEI+ LI   +    NIVR+   E D  FVYL L  C  SL +L++   +    S+ N+    +   +  I  +LRL                       L L++D+V G+  LH+ GI+H DL P+N+LI  +R +   +SD+G+S+  +    S   HA   G  G+   E LL  R T++V+  S  C+LF+ + GGQHP GD+  R  NI   KPI
Sbjct: 1060 IGRGSNGTLVFKGIWNDRIPVAIKQMHKAFNPLISKEIEVLITLTNKNCNNIVRYIDQEEDDMFVYLGLTLCNGSLQNLVEKDLEINLISTSNNENNNNNKLKNFIGSELRL-----------------------LELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFI---ISDLGLSKMEVTSSYSFTMHAP-TGQEGFHPAEVLLEKRKTKSVDIFSMGCILFYLMTGGQHPFGDKFFRMANILTDKPI 1287          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: IREA_DICDI (Probable serine/threonine-protein kinase ireA OS=Dictyostelium discoideum GN=ireA PE=3 SV=1)

HSP 1 Score: 132.494 bits (332), Expect = 3.381e-30
Identity = 89/254 (35.04%), Postives = 133/254 (52.36%), Query Frame = 1

Query:   22 VSNTEIAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQ---TYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHG--RATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINIYK 768
            ++N  +  GS GT+VYEG  EGR VAVKR++      A +E+  LI SD+H N+VR+Y  E D +F+YL++  C  SLD  +Q   +   S  +S   +              ++ ++II + +              ++ +L  GL HLH L I+HRD+KP NVLI     +  K+SDMG+ + L  D  SL   +    S GWQ P + L+G  R T+ V+  S  CV+++ + G  HP G R  R  N+ K
Sbjct:  576 ITNKILGTGSCGTIVYEGKMEGRKVAVKRMLSQFVKFADREVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKT------------KQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRV--KISDMGLGKLLDNDDQSLTFTS---DSHGWQ-PAEYLNGTNRNTKKVDIFSLGCVVYYLLTGA-HPFGHRYNREKNVLK 810          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: ERN1_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2)

HSP 1 Score: 131.339 bits (329), Expect = 7.532e-30
Identity = 77/254 (30.31%), Postives = 118/254 (46.46%), Query Frame = 1

Query:   19 FVSNTEIAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHG---RATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINI 762
            F     +  G+ GT+VY G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L++   SGL HLH L I+HRDLKP N+LI    +   + A +SD G+ ++L     S    +   G+ GW APE L        T  V+  S  CV ++ I  G HP G  L+R  NI
Sbjct:  571 FCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANI 785          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: ERN1_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Mus musculus GN=Ern1 PE=2 SV=1)

HSP 1 Score: 130.568 bits (327), Expect = 1.285e-29
Identity = 76/254 (29.92%), Postives = 118/254 (46.46%), Query Frame = 1

Query:   19 FVSNTEIAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQL---LHGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINI 762
            F     +  G+ GT+VY+G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L+    SGL HLH L I+HRDLKP N+L+    +   + A +SD G+ ++L     S    +   G+ GW APE L        T  V+  S  CV ++ I  G HP G  L+R  NI
Sbjct:  571 FCPKDVLGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKKLAVGRHSFSRRSGVPGTEGWIAPEMLSEDCKDNPTYTVDIFSAGCVFYYVISEGNHPFGKSLQRQANI 785          

BLAST of EY679879 vs. ExPASy Swiss-Prot
Match: IRLC_DICDI (Probable serine/threonine-protein kinase irlC OS=Dictyostelium discoideum GN=irlC PE=3 SV=1)

HSP 1 Score: 129.028 bits (323), Expect = 3.738e-29
Identity = 87/251 (34.66%), Postives = 134/251 (53.39%), Query Frame = 1

Query:   37 IAKGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIASDQHP--NIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRLLGDMSSLGHHATGCGSSGWQAPEQLLHGRATRAVEFVSYSCVLFFCIPGGQHPLGDRLERNINIY-KKPI 777
            + +GSNGT+V++GI+  R PVA+K++ +  + +  KEI+ LI        NIVR+   E D+  VYL L  C  SL +L++   ++   + F         + Y +   S           K N      LL L++D+V G+  LH+ GI+H DL P+N+LI  +R +   +SD+G+S+  +    S   HA   G  G+   E LL  R T++V+  S  C+LF+ + GGQHP GD+  R +NI   KPI
Sbjct:  987 LGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIEVLITLTNKNCYNIVRYIDQEEDESCVYLGLTLCDGSLQNLVEKGDNNLTLTQF---------LGYDINSSS-----------KNNSR----LLELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFI---ISDLGLSKMEVTSSYSFTMHAP-TGQEGFHPAEVLLEKRKTKSVDIFSMGCILFYLMTGGQHPFGDKFYRIVNILTDKPI 1209