EY679740

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: IRE1_YEAST (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Saccharomyces cerevisiae GN=IRE1 PE=1 SV=2)

HSP 1 Score: 113.235 bits (282), Expect = 2.255e-24
Identity = 72/215 (33.49%), Postives = 107/215 (49.77%), Query Frame = 2

Query:    5 LFVSNT*IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAK-----------LSDMGISRRPPWGYVFFGVIMLPVGGSSG 616
            L VS   +  GS+GTVV++G ++GRPVAVKR++    D+A  EI+ L  SD HPN++R+Y  E    F+Y++LE C  +L DL+++ + S        D+  +   EY                           +SL+R + SG+ HLH L IIHRDLKPQN+L+       A            +SD G+ ++   G   F   +    G+SG
Sbjct:  673 LVVSEKILGYGSSGTVVFQGSFQGRPVAVKRMLIDFCDIALMEIKLLTESDDHPNVIRYYCSETTDRFLYIALELCNLNLQDLVESKNVS--------DENLKLQKEYN-------------------------PISLLRQIASGVAHLHSLKIIHRDLKPQNILVSTSSRFTADQQTGAENLRILISDFGLCKKLDSGQSSFRTNLNNPSGTSG 854          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: PPK4_SCHPO (Serine/threonine-protein kinase ppk4 OS=Schizosaccharomyces pombe GN=ppk4 PE=2 SV=1)

HSP 1 Score: 109.383 bits (272), Expect = 3.256e-23
Identity = 68/184 (36.96%), Postives = 98/184 (53.26%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS-------LCAKLSDMGISRR 556
            I  GS+GT+VY G+YE R VAVKR++   +D+A +EI  L  SD HPNIVR+Y  +    F+Y+ +E C C+L DLI+                              K I  D  L+K     S  L+SL+  +  G+ HLH L ++HRDLKPQN+L++   S       + A +SD G+S++
Sbjct:  660 IGYGSHGTIVYRGVYEDREVAVKRVLMEFYDLASREITLLQQSDNHPNIVRYYCKQKSDQFLYIVIELCKCNLSDLIE------------------------------KPIAYD-DLFK-----SIDLVSLLYQIAFGVSHLHSLDLVHRDLKPQNILLVVNNSPNLSKTRVRALISDFGLSKK 807          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: IREA_DICDI (Probable serine/threonine-protein kinase ireA OS=Dictyostelium discoideum GN=ireA PE=3 SV=1)

HSP 1 Score: 102.064 bits (253), Expect = 5.198e-21
Identity = 64/184 (34.78%), Postives = 98/184 (53.26%), Query Frame = 2

Query:   11 VSNT*IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQ---TYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISR 553
            ++N  +  GS GT+VYEG  EGR VAVKR++      A +E+  LI SD+H N+VR+Y  E D +F+YL++  C  SLD  +Q   +   S  +S   +              ++ ++II + +              ++ +L  GL HLH L I+HRD+KP NVLI     +  K+SDMG+ +
Sbjct:  576 ITNKILGTGSCGTIVYEGKMEGRKVAVKRMLSQFVKFADREVSILIHSDEHTNVVRYYAKEEDDEFIYLAISFCQKSLDMYVQQTLSLQISPTDSPSIQSSNNNGNGNNGNNNNNNQIIIDNKT------------KQMILELFKGLEHLHSLNIVHRDIKPHNVLIDPNNRV--KISDMGLGK 745          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: IRE1_CAEEL (Serine/threonine-protein kinase/endoribonuclease ire-1 OS=Caenorhabditis elegans GN=ire-1 PE=2 SV=2)

HSP 1 Score: 99.3673 bits (246), Expect = 3.369e-20
Identity = 78/253 (30.83%), Postives = 119/253 (47.04%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLII---KERSLCAKLSDMGISRRPPWGYVFFGVIMLPVGGSSGLEST--W--SNFLHGKENSGWLNLITLKSLPVFLHHWGVYIPFGDPLKKKNHI 763
            +  G  GTVVY G ++GR VAVKR+V      A +E   L  SD HP+++R++ +E+D  F YL+LE C+ SL+D                       +E K    +V + +RD                +M+    GL HLH   I+HRD+KPQNVLI    +   + A +SD G+ +R     V  G   +  G +SGL  T  W     L     S  +++ +L  +  ++   G + PFG  L ++ +I
Sbjct:  524 LGTGCEGTVVYRGTFDGREVAVKRVVSEFVKFAHREADLLRESDTHPHVIRYFCMESDSQFRYLALELCIASLND----------------------YVEQKEVQQNVTIALRD----------------IMKQATDGLAHLHASKIVHRDMKPQNVLITMASQRGEMRAVISDFGLCKR-----VQPGKNSISRGIASGLAGTDGWIAPEVLISASTSYPVDIFSLGCIFYYVLTSGTH-PFGKSLHRQANI 732          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: ERN2_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Mus musculus GN=Ern2 PE=2 SV=1)

HSP 1 Score: 95.9005 bits (237), Expect = 3.725e-19
Identity = 61/190 (32.11%), Postives = 93/190 (48.95%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRPPWGYVFFGV 586
            + +G+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E+   F Y++LE C  SL + +++                                  DL  W     P+ +L  +M    SGL HLH L I+HRDLKP N+L+    S       +SD G+ ++ P G   F +
Sbjct:  514 LGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTEHGPQFHYIALELCQASLQEYVES---------------------------------PDLDRWGL--EPTTVLQQMM----SGLAHLHSLHIVHRDLKPANILMAGPDSQGQGRVVISDFGLCKKLPVGRCSFSL 664          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: ERN1_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Homo sapiens GN=ERN1 PE=1 SV=2)

HSP 1 Score: 95.9005 bits (237), Expect = 3.725e-19
Identity = 53/180 (29.44%), Postives = 88/180 (48.89%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRR 556
            +  G+ GT+VY G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L++   SGL HLH L I+HRDLKP N+LI    +   + A +SD G+ ++
Sbjct:  577 LGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCKK 717          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: ERN1_MOUSE (Serine/threonine-protein kinase/endoribonuclease IRE1 OS=Mus musculus GN=Ern1 PE=2 SV=1)

HSP 1 Score: 95.1301 bits (235), Expect = 6.354e-19
Identity = 52/180 (28.89%), Postives = 88/180 (48.89%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERS---LCAKLSDMGISRR 556
            +  G+ GT+VY+G+++ R VAVKR++      A +E+Q L  SD+HPN++R++  E D+ F Y+++E C  +L + ++                                        K   H     ++L+    SGL HLH L I+HRDLKP N+L+    +   + A +SD G+ ++
Sbjct:  577 LGHGAEGTIVYKGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQ---------------------------------------KDFAHLGLEPITLLHQTTSGLAHLHSLNIVHRDLKPHNILLSMPNAHGRIKAMISDFGLCKK 717          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: ERN2_HUMAN (Serine/threonine-protein kinase/endoribonuclease IRE2 OS=Homo sapiens GN=ERN2 PE=1 SV=2)

HSP 1 Score: 93.9745 bits (232), Expect = 1.415e-18
Identity = 60/190 (31.58%), Postives = 92/190 (48.42%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGRPVAVKRLVRALHDVAFKEIQNLIASDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSL---CAKLSDMGISRRPPWGYVFFGV 586
            + +G+ GT V+ G +EGR VAVKRL+R    +  +E+Q L  SD+HPN++R++  E    F Y++LE C  SL + ++                 R  +E ++                           +++ L+SGL HLH L I+HRDLKP N+LI    S       LSD G+ ++ P G   F +
Sbjct:  526 LGRGAGGTFVFRGQFEGRAVAVKRLLRECFGLVRREVQLLQESDRHPNVLRYFCTERGPQFHYIALELCRASLQEYVE------------NPDLDRGGLEPEV---------------------------VLQQLMSGLAHLHSLHIVHRDLKPGNILITGPDSQGLGRVVLSDFGLCKKLPAGRCSFSL 676          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: IRLD_DICDI (Probable serine/threonine-protein kinase irlD OS=Dictyostelium discoideum GN=irlD PE=3 SV=1)

HSP 1 Score: 89.7373 bits (221), Expect = 2.669e-17
Identity = 62/183 (33.88%), Postives = 99/183 (54.10%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIA--SDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSD----SSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISR 553
            I +GSNGT+V++GI+  R PVA+K++ +A + +  KEI+ LI   +    NIVR+   E D  FVYL L  C  SL +L++   +    S+ N+    +   +  I  +LRL                       L L++D+V G+  LH+ GI+H DL P+N+LI  +R +   +SD+G+S+
Sbjct: 1060 IGRGSNGTLVFKGIWNDRIPVAIKQMHKAFNPLISKEIEVLITLTNKNCNNIVRYIDQEEDDMFVYLGLTLCNGSLQNLVEKDLEINLISTSNNENNNNNKLKNFIGSELRL-----------------------LELIKDIVYGIQFLHQQGIVHNDLNPRNILIKDDRFI---ISDLGLSK 1216          

BLAST of EY679740 vs. ExPASy Swiss-Prot
Match: IRLE_DICDI (Probable serine/threonine-protein kinase irlE OS=Dictyostelium discoideum GN=irlE PE=3 SV=1)

HSP 1 Score: 85.5001 bits (210), Expect = 5.034e-16
Identity = 67/250 (26.80%), Postives = 119/250 (47.60%), Query Frame = 2

Query:   26 IAKGSNGTVVYEGIYEGR-PVAVKRLVRALHDVAFKEIQNLIA-SDQHPNIVRWYGVENDKDFVYLSLERCMCSLDDLIQTYSDSSCNSVFGEDQATRAMIEYKLRLDSVKVIIRDLSLWKANGHPSPLLLSLMRDLVSGLVHLHELGIIHRDLKPQNVLIIKERSLCAKLSDMGISRRPPWGYVFFGVIMLPVGGSSGLESTWSNFLHGKENSGWLNLITLKSLPVFLHHWGVYIPFGDPLKKKNHINK 769
            + +GSNGT+V++GI+  R PVA+K++ +  + +  KEI+ LI  ++++ N+V +   E D++ VYL L  C  SL  L   Y  S  N    ++                            N + +  +L L+  +++G++ LH+  I+H DL P+N+L+   R +   +SD+G+S+        F    +P  G  G        L  K  +  +++ +L  L  F+   G + PFGD   +  +I K
Sbjct:  909 LGRGSNGTLVFKGIWNNRIPVAIKQMQKMFNPLISKEIEILIGLTNKNLNLVGYIDQEEDENCVYLGLTLCDGSLQSL---YDQSKLNEFINQNNNQN------------------------NNNNNNRVLDLIIGMINGVIFLHDQNIVHNDLNPRNILVKDNRLI---ISDLGLSKMNVSSTYNFSTNAIPT-GQDGYHPV--EVLLEKRKTKSVDVFSLGCLIYFIMTNGAH-PFGDKFSRLRYITK 1124