EVM_prediction_chr2.1_tiancheng.2251

Query:   13 FVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMAS----ISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            FV+P+   EE KQP YL+PWD  MLSVQYIQKGLLF KP +        D I TLL++LK SL++TLVHFYPLAGRL +  T+ P SY VFVDCN+SPGA FI+A+ D+ I DI+   YVP +VQSFFDH +A+NHDGH+  LLS+QVTELVDGIFIG SMNH +GDGT+FW FF A+SEIFQ Q    +    +  PPV+KR+ P+G  P+ +LP++H DEFIR YE+P L ER+F F+ E+I  LK + N   G  T  ISSFQ+L+A++WR ITR R LP D+ T CR+AADNR R+ PPL ++YFGN ++ LR     GELL +DLG+AA K+HQ V   T + V + +D W KSP++YH+DRLF+P S+MMGSSPRFNKYG EFGLG+ V LRSGYAHKFDGKVSAYPG EGGGSIDLE+CL P  M ALE+DEEFM   S
Sbjct:   14 FVKPKTLPEESKQPYYLSPWDYAMLSVQYIQKGLLFHKPPL--------DSIDTLLEKLKDSLAVTLVHFYPLAGRLSSLTTEKPKSYSVFVDCNDSPGAGFIYATSDLCIKDIVGAKYVPSIVQSFFDHHKAVNHDGHTMSLLSVQVTELVDGIFIGLSMNHAMGDGTAFWKFFTAWSEIFQGQESNQNDDLCLKNPPVLKRYIPEGYGPLFSLPYSHPDEFIRTYESPILKERMFCFSSETIRMLKTRVNQICG--TTSISSFQSLTAVIWRCITRARRLPLDRETSCRVAADNRGRMYPPLHKDYFGNCLSALRTAAKAGELLENDLGFAALKVHQAVAEHTSEKVSQMIDQWLKSPYIYHIDRLFEPMSVMMGSSPRFNKYGCEFGLGKGVTLRSGYAHKFDGKVSAYPGREGGGSIDLEVCLVPEFMEALESDEEFMSLVS 449          

Query:    2 NSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQ-GKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVT-TVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFM 450
             S  V+ +S+CFV+P+   E+ K+P +L+P DLVMLS+ Y+Q GLLF K      +    DF++T L +L+ SL+ TLVHFYPLAGRL T +TD+P SY VFVDCN+SPGA FIHA  D+++ DI+   YVPLVVQSFFDH +A++HDGH+  L S++VTELVDG+FIG S+NH +GDG S W+FFN+ SEIF AQ      +  PPV+ RWFP G  P+ NLPFTH DEFI R+E+P L ERIFHF+ E+I  LK+KAN E+   T  ISSFQAL+A +WR ITR RNLP D    C +AA+N  +L+PPL   Y GN ++ ++  T T GELL +DLGWAA K+H+ V+  T + V E +  W KS +++HL++L     + +GSSPRF  Y  EFG+G+AVA+RSGY  KFDGK+SAY G EGGG+IDLE+CL P  M ALE+D+EFM
Sbjct:    4 TSSEVKIVSQCFVKPKTIPEKWKEPYHLSPLDLVMLSMHYLQNGLLFLKS---DDATKTKDFMETWLQKLRDSLAETLVHFYPLAGRLSTLKTDNPRSYSVFVDCNDSPGAGFIHAKSDLSVRDIVGSNYVPLVVQSFFDHHKAVSHDGHTMSLFSVKVTELVDGVFIGFSLNHAVGDGGSLWHFFNSLSEIFNAQETDNLLLKNPPVLSRWFPKGYGPVYNLPFTHSDEFISRFESPVLKERIFHFSSETITSLKSKANEES--RTTTISSFQALAAFMWRCITRARNLPYDHEIRCSLAANNGTKLDPPLSLSYLGNCLSAVKSKTVTSGELLENDLGWAALKMHEAVIGNTSEVVSETIKNWLKSSYVFHLEKLLGAMVVHIGSSPRFKMYECEFGMGKAVAVRSGYGGKFDGKISAYAGREGGGTIDLEVCLLPEFMEALESDQEFM 449          

Query:    2 NSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGK------------MASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            +S  V+ +S+CFV+P+   ++ K+P + +P D +MLS+ YIQKGLLF KP+    SV   +F++TLL +LK SL++ LVHFYPLAGRL T +TD+  S+ VFVDCNNSPGA+FIHA  D+++SDIL  TYVPLVVQS FDH +ALN DG++  LLSI+VTELVDG+FIG SMNH LGDG+SFW FFN+ SEIF +Q +            +  +  PP+I+    +   P+ +LPF+  +E + + E P L ER+FHF+ E++  LK+KAN E G  T  ISSFQAL+AL+WRSITR R LP DQ T CR AA NR R+ PPLP   FG  I+ ++  T +G LL ++ GW A KLHQ V   T + +   +D   KSP      RL +   + MGSSPRFNKYG+EFG+G+AVA+RSGY  K+DGKVSAYPG +GG SIDLE+CL P  M ALE+D+EFM   S
Sbjct:    4 SSSEVRIISKCFVKPKTIPQKWKEPYHFSPTDHIMLSIHYIQKGLLFLKPSFS-ESVKPKEFMETLLQKLKDSLAIALVHFYPLAGRLSTLKTDNSRSHSVFVDCNNSPGARFIHAESDLSVSDILGSTYVPLVVQSLFDHHKALNRDGYTMSLLSIKVTELVDGVFIGLSMNHSLGDGSSFWQFFNSLSEIFNSQEETIGNNNNNNNNALLCLKNPPIIR----EATGPMYSLPFSEPNESLSQSEPPVLKERMFHFSSETVRSLKSKANQECG--TTMISSFQALTALIWRSITRARKLPNDQETTCRFAAGNRSRMNPPLPTNQFGVYISLVKTTTKIGNLLENEFGWIALKLHQAVTEHTGEKISYEIDQMLKSPLPLQAYRLSNLNIVHMGSSPRFNKYGSEFGMGKAVAVRSGYGGKYDGKVSAYPGRQGGASIDLEVCLLPEFMEALESDQEFMSLVS 461          

Query:    2 NSPA-VQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQ---GKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFM 450
            +SP+ V+ +S+CFV+P+   E+ K+P + +P D V+LS+ YIQKGLLF KP+    SV   +F++TLL +LK SL++ LVHFYPLAGR+ T +T+   S+ VFVDCNNSP A FIHA  D+++SDIL   YVPLVVQSFFDH +AL+ DG +  LLS++VTELVDG+FIG SMNH LGDG+SFW+FFN+ SEIF +Q    K   +  PP+    F +   P+ +LPF+  DE I + E P L ER+FHF+ E++  LK+KAN E G  T KISS Q+L+AL+WRSITR R LP DQ T CR+AA NR R+ PPLP  +FGN I+ +   TT G+LL ++ G AA KLHQ V   T + +   +D W K+     LD  F P  + MGSSPRFNKYG+EFG+G+AVA+RSGY  K+DGKVSAYPG EGG SIDLE+CLPP  M ALE D+EFM
Sbjct:    3 SSPSEVKIISKCFVKPKTIPEKWKEPYHFSPMDHVILSIHYIQKGLLFLKPSFS-ESVTPKEFMETLLQKLKDSLAIALVHFYPLAGRISTLKTNDSRSHSVFVDCNNSP-AGFIHAESDLSVSDILGSKYVPLVVQSFFDHHKALSRDGDTMTLLSVKVTELVDGVFIGLSMNHSLGDGSSFWHFFNSLSEIFNSQEDNNKFLCLKNPPI----FREVSGPMYSLPFSEPDESISQSERPVLKERMFHFSSETVRSLKSKANEECG--TTKISSLQSLTALIWRSITRARKLPNDQETTCRLAAGNRSRMNPPLPMNHFGNYISLVIATTTTGDLLENEFGCAALKLHQAVTEHTGEKISADMDRWLKAHL--KLDGFFSPNIVHMGSSPRFNKYGSEFGMGKAVAVRSGYGGKYDGKVSAYPGREGGASIDLEVCLPPECMEALELDQEFM 445          

Query:   29 LTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHA-SLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEA---------------GNNTN-------------------------------KISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFM 450
            L+  DL MLS  YIQKG LF  P +P         +  L+  LKHSLS+TL HF PLAGRL T  +       VF+ CN++ GA F+ A +  + +SD+++   VP VV+ FF +DRA++++GH+RP+L++QVTEL DG+FIGCS+NH + DGTS WNF N F+E+ +      +++R P   R        ++ +P       +   E   L ERIF F+ ESI  LKA  N +                G  +N                               +ISSFQ+L AL+WR+ITR R LP  +TT  RMA + R RL P L  EYFGN+I  +    T  E+L  DL W A +L+Q+V    D  +R  +  W  +P  + L    D  S+ MGSSPRF  Y N+FG G+ VA+RSG ++KFDGK+SA+PG EG G++DLE+ L P +M  +E+D EFM
Sbjct:   29 LSVSDLPMLSCHYIQKGCLFTCPNLP---------LPALISHLKHSLSITLTHFPPLAGRLSTSSSGH-----VFLTCNDA-GADFVFAQAKSIHVSDVIAGIDVPDVVKEFFTYDRAVSYEGHNRPILAVQVTELNDGVFIGCSVNHAVTDGTSLWNFINTFAEVSRGA---KNVTRQPDFTRESVLISPAVLKVP--QGGPKVTFDENAPLRERIFSFSRESIQELKAVVNKKKWLTVDNGEIDGVELLGKQSNDKLNGKENGILTEMLESLFGRNDAVSKPVAVEISSFQSLCALLWRAITRARKLPSSKTTTFRMAVNCRHRLSPKLNPEYFGNAIQSVPTFATAAEVLSRDLKWCADQLNQSVAAHQDGRIRSVVADWEANPRCFPLGNA-DGASVTMGSSPRFPMYDNDFGWGRPVAVRSGRSNKFDGKISAFPGREGNGTVDLEVVLSPETMAGIESDGEFM 476          

Query:    6 VQYMSECFVQPEYFSEEMKQ-PCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASL-DMAISDILSP--TYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEI-FQAQGKMASISRPPVIKR-WFPDGRDPIINLPFTHRDEFIRRYEAPQLL-ERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME 451
            V  +S+  V+PE ++EE  +   +LTPWDL  L  +Y Q+GLLF +P          D    ++ +LK SLS+ L  FYP AGRLV  + +   +   +VDC+ S G KFIHAS   +++SD+L P  + VP  +  FF  +   + +G S  L++ QVTEL DG+FIG   NH++ DG+SFW+FFN +SEI F           PP++ R WF DG +  I +P    +   R      LL E+IF  T  +I+ LKAKAN E  ++  KISS QA+SA +WRSI R   L P++   C++  D R RL PPL +E FGN +      TTV E+L + LGWAA ++++TV +QT++  RE+ + W K P + +     +  SI + SSPRFN YGN+FG G+ +A+R+G  +  DGK+ AYPG E  G+I+ + CL    +  L  DEEF++
Sbjct:    5 VVVISKSIVRPESYNEESDRVKIHLTPWDLFFLRSEYPQRGLLFPQP----------DPETHIISQLKSSLSVALKIFYPFAGRLVKVENEDAGTASFYVDCDGS-GVKFIHASAKSVSVSDVLEPVDSNVPEFLNRFFPANGVRSCEGISESLIAFQVTELKDGVFIGFGYNHIVADGSSFWSFFNTWSEICFNGFDADHRRKFPPLLLRGWFLDGIEYPIRIPLPETETPNRVVVTSSLLQEKIFRVTSRNISELKAKANGEVDSDDRKISSLQAVSAYMWRSIIRNSGLNPEEVIHCKLLVDMRGRLNPPLEKECFGNVVGFATVTTTVAEMLHNGLGWAALQINKTVGSQTNEEFREFAENWVKKPSILNAKAFSN--SITIASSPRFNVYGNDFGWGKPIAVRAGPGNTTDGKLIAYPGIE-EGNIEFQTCLSSSVLEKLSTDEEFLK 443          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPA-SVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLD-MAISDILSPTY-VPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASI---SRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQ-LLERIFHFTGESIARLKAKAN----------------------------------AEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            M S +V  +S+C V PE   +       L+  DL MLS  YIQKG+L   P  PP+ S D +            SLS TL  F  LAGR  T    +P  ++  V CN++ G  F+ AS   + +SD+L P   VPL+ + FF  +R ++++GH +PL ++QVTEL DG+FIGC++NH + DGTSFW+FFN F+++     K+  +   SR  V         D  + LP       +  ++A Q L ERIFHF+ E+I +LK + N                                   ++ + T +ISSFQ+LSA +WRS+TR RNL P +TT  RMA + R RLEP +   YFGN+I  +  + + G+LL  DL W+A +LH+ VV   D  VR  + AW   P ++ L    D  SI MGSSPRF  Y N+FG G+ +A+RSG A+KFDGK+SA+PG EG GS+DLE+ L P +MT +E D EFM+  S
Sbjct:    1 MPSCSVTEISKCIVYPE--KKSTVSDLRLSVSDLPMLSCHYIQKGVLLTSP--PPSFSFDDLVSSLRR------SLSSTLSLFPALAGRFST----TPAGHISIV-CNDA-GVDFVAASAKHVKLSDVLLPGEDVPLLFREFFVFERLVSYNGHHKPLAAVQVTELHDGVFIGCTVNHSVTDGTSFWHFFNTFADVTSGACKIKHLPDFSRHTVF--------DSPVVLPVPPGGPRVT-FDADQPLRERIFHFSREAITKLKQRTNNRVNGIETAVNDGRKCNGEINGKITTVLDSFLNNKKSYDRTAEISSFQSLSAQLWRSVTRARNLDPSKTTTFRMAVNCRHRLEPKMDPYYFGNAIQSIPTLASAGDLLSKDLRWSAEQLHRNVVAHDDATVRRGIAAWESDPRLFPLGNP-DGASITMGSSPRFPMYDNDFGWGKPLAVRSGGANKFDGKISAFPGREGNGSVDLEVVLAPETMTGIENDAEFMQYVS 469          

Query:    6 VQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLD-MAISDILSPT-YVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFI-RRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYH--LDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME 451
            V ++S   V+P+  ++E ++  +LTP+DL +L V Y Q+GLLF KP          D     + RL+ SLS  L  ++P AGRL   +     +   +++C+ S GAKFIHA  D +++SD+L P   VP   + F+  +   + DG S PLL++QVTE+ DG+FIG   NH++ DG S WNFF  +S+I  + G+  ++ +P  +K  F DG D  I++P +  +     R  +P   ER+FHFT  +I+ LKAK N E G   +K+SS QA+SA +WRSI R   L  ++ T C +A D R RL PPL +E FG+ I      TTVGEL    LGWA  +++  + + T++  R + + W ++  +    L       S+++ SSPRF  Y N+FG G+ +A+R+G ++   GK+  + G E  G ID+   L P  +  L AD EF+E
Sbjct:    4 VTFISSSIVRPQIINQEGREKIHLTPFDLNLLYVDYTQRGLLFPKP----------DPETHFISRLRTSLSSALDIYFPFAGRLNKVENHEDETVSFYINCDGS-GAKFIHAVSDSVSVSDLLRPDGSVPDFFRIFYPMNGVKSIDGLSEPLLALQVTEMRDGVFIGFGYNHMVADGASIWNFFRTWSKIC-SNGQRENL-QPLALKGLFVDGMDFPIHIPVSDTETSPPSRELSPTFKERVFHFTKRNISDLKAKVNGEIGLRDHKVSSLQAVSAHMWRSIIRHSGLNQEEKTRCFVAVDLRQRLNPPLDKECFGHVIYNSVVTTTVGELHDQGLGWAFLQINNMLRSLTNEDYRIYAENWVRNMKIQKSGLGSKMTRDSVIVSSSPRFEVYDNDFGWGKPIAVRAGPSNSISGKLVFFRGIE-EGCIDVHAFLLPDVLVKLLADVEFLE 440          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHA-SLDMAISDILSPT-YVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYE---APQLLERIFHFTGESIARLKAKANAEAGNNTN-KISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME 451
            M    V  +S   V+P   S+  +   +LTP+DL +L   Y Q+GLLF KP          DF   ++ RLK SLSL L  ++P AGRLV  +     +   F+DC+ S GA+F+H  +  +++SDIL P   VP  ++ FF  D   + DG S PLL IQVTE+ DG+FI    NH++ DG S W+FF+ +S+I           +P V+K WF +G D  I++P +  +      E    P   E IFHFT ++I+ LKAKAN+E  ++++ ++SS QA+SA +WRSI R   +  +Q T CR+  D R R+ PPL ++ FGN +     +TTV ELL   LG AA ++ + V +QT++  + + + W ++  + +L+         +I++ SSPRF  Y  +FG G+ +A+R+G ++  +GK+S + G    GSID++  L    +  L AD EF+E
Sbjct:    1 MAGGGVVLVSSSIVRPVNSSQSGRTKIHLTPFDLSLLQFDYPQRGLLFSKP--------DSDF-HLIISRLKDSLSLALEIYFPFAGRLVKTENLEDDTVSFFIDCDGS-GARFLHTEAKSVSVSDILQPDGSVPDFLKYFFPADDFKSCDGVSLPLLVIQVTEMKDGVFISFCYNHMVADGVSMWSFFDTWSKICSTGSCFNY--KPLVLKGWFLEGIDYPIHVPVSEAERSPPSREPSSVPITKEWIFHFTKKNISDLKAKANSEIASSSDLEVSSLQAVSAHMWRSIIRHSGVSREQKTHCRLVVDLRQRVNPPLEKDCFGNMVYLSSAITTVEELLDRGLGEAALQIRKLVSSQTNETCKSFAEDWVRN--IKNLNSGIGSKVGNTIVIASSPRFEVYNKDFGWGKPIAIRAGPSNSINGKLSVFQGIS-EGSIDVQAILWGDVIVKLLADLEFLE 445          

Query:    6 VQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLD-MAISDILSP-TYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLD---RLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICL 435
            V  +S   VQP       ++  +LTP DL +L + Y Q+ LLF KP   P +          + RLK SLS +L  ++PLAGRLV        +   ++DC++  G KF+HA  + +++SDIL P   VP   + FF  +   + DG S PLL++QVTE+ DGI I    NH++ DG+S WNF + +S++         I +P V++ WF D  D  I++P +  +    R       ER+FHFT E ++ LKAKAN E G++  KISS QA+ A +WRSI R   L  ++ + C +AAD R RL PPL ++ FGN  N      TVG+LL   LGWAA ++++TV   T++  R + + W ++  +  +D   R+ D    M+ +SP F  Y N+FGLG+ +A+R+G A+   GK+  + G E  GSID+   L
Sbjct:    4 VTVISSSIVQPGNARHSGREKIHLTPSDLSLLYLNYPQRSLLFPKPY--PET--------RFISRLKSSLSTSLEIYFPLAGRLVKVNNHEDNTVSFYIDCDDGRGVKFVHAIAESVSVSDILQPHGSVPDFFRLFFPMNGVRSIDGLSEPLLALQVTEIKDGIVISFGYNHLVADGSSMWNFIHVWSKL--CLNGQWEIHQPLVLRGWFLDNIDFPIHIPASEIETERARNREVSTKERVFHFTKEKLSDLKAKANDEIGSSDIKISSLQAVLAHLWRSIVRHSGLNQEEESRCGVAADFRQRLNPPLDKDCFGNVANLGLTTATVGDLLDRGLGWAALQINKTVRLHTNENFRTFSENWVRNGKIPRIDVRSRMGD-HGFMVSNSPWFQVYDNDFGLGKPMAVRAGPANGIGGKLVVFRGIE-EGSIDVHAIL 424          

Query:    6 VQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLD-MAISDILSPT-YVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFI-RRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYH--LDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME 451
            V ++S   V+P+  ++E ++  +LTP+DL +L V Y Q+GLLF KP          D     + RL+ SLS  L  ++P AGRL   +     +   +++C+ S GAKFIHA  D +++SD+L P   VP   + F+  +   + DG S PLL++QVTE+ DG+FIG   NH++ DG S WNFF  +S+I  + G+  ++ +P  +K  F DG D  I++P +  +     R  +P   ER+FHFT  +I+ LKAK N E G   +K+SS QA+SA +WRSI R   L  ++ T C +A D R RL PPL +E FG+ I      TTVGEL    LGWA  +++  + + T++  R + + W ++  +    L       S+++ SSPRF  Y N+FG G+ +A+R+G ++   GK+  + G E  G ID+   L P  +  L AD EF+E
Sbjct:    4 VTFISSSIVRPQIINQEGREKIHLTPFDLNLLYVDYTQRGLLFPKP----------DPETHFISRLRTSLSSALDIYFPFAGRLNKVENHEDETVSFYINCDGS-GAKFIHAVSDSVSVSDLLRPDGSVPDFFRIFYPMNGVKSIDGLSEPLLALQVTEMRDGVFIGFGYNHMVADGASIWNFFRTWSKIC-SNGQRENL-QPLALKGLFVDGMDFPIHIPVSDTETSPPSRELSPTFKERVFHFTKRNISDLKAKVNGEIGLRDHKVSSLQAVSAHMWRSIIRHSGLNQEEKTRCFVAVDLRQRLNPPLDKECFGHVIYNSVVTTTVGELHDQGLGWAFLQINNMLRSLTNEDYRIYAENWVRNMKIQKSGLGSKMTRDSVIVSSSPRFEVYDNDFGWGKPIAVRAGPSNSISGKLVFFRGIE-EGCIDVHAFLLPDVLVKLLADVEFLE 440          

Query:    9 MSECFVQPEYFSEEMK-QPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHA-SLDMAISDILSPT-YVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMA-SISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            +S+  V P    +    +   LTPWDL  L   Y+Q+GLLF K  +                +L+ SLS+ L  FYPLAGRLV  + D   +   F+ C+ S G +F+HA + ++ +SD+L  +  VP    SFF      N+ G SR LL +QVTE+ DG+FIG   N  + D TS W F NA+SEI       + +  R   +K WF D  D  I++P               L E++FH T E++ +L AKAN EA     KISS QA+ A +WRS+ +   +  ++ T CR+  + R RL PPL  E FGN         TVGELL H LGWAA +++   ++QTD+  + + + W K+     +        +++ +S RF+ Y N+FG G+ +A R+G  +  +G++  + G  G  S+D + CL P  +  L  D EF E  S
Sbjct:    8 ISKSIVNPRSLKKPTSVKKIQLTPWDLSRLRFGYLQRGLLFHKIEVK---------------QLQASLSVALDRFYPLAGRLVKLKNDDD-TVSFFISCDGS-GVEFVHAVAKNIELSDVLELSGSVPGFFASFFPATGIKNYHGVSRSLLMVQVTEMKDGVFIGFGYNSTVADATSIWKFINAWSEICSKDSSGSQTFQRRLHLKGWFFDEIDYPIHIPDPETKPTSYVTTPTNLQEKMFHVTKENVLKLDAKANDEA---DQKISSIQAVLAYIWRSMVKHSGMSREEETHCRLPINMRQRLNPPLEEECFGNVSQTGIATVTVGELLDHGLGWAAMQINNMELSQTDEKAKAFAENWVKN---IKIPVSVGSKDLVVTNSHRFDVYCNDFGWGKPIAARAGPPY-LNGRLVVFKGI-GEASLDFQACLLPQVVEKLVKDAEFNEYVS 432          

Query:    6 VQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSP--GAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTH----------RDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNK-ISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFM 450
            ++ MS+  V+P       KQ  +LT +DL  L+  Y QK LL++   +    +++  F   +++ LK  L L L  FY LAG+L     D    + V  D  +S   G +F  A       D L+        +    ++  LN +G SRPLL++QVT+L DG+ +G + NH + DGTS W+F ++++EI +      SIS  P + R     RD  + L  T            D      E PQL+E+IF F+  ++  +K++AN+   ++++K  S+FQ+L++ +WR +T  R L P+  T   + AD R R++PP+P EYFGN I  +   T  G L  H   + A  + + +       +    D W KSP ++   +      + +GSSPRF  Y  +FG G+   +RSG  ++F+G +  Y G  GG SID+EI L    M  L   +EF+
Sbjct:    3 IKIMSKTHVKPTKPVLGKKQ-FHLTTFDLPYLAFYYNQKFLLYKFQNL--LDLEEPTFQNEVVENLKDGLGLVLEDFYQLAGKLAK---DDEGVFRVEYDAEDSEINGVEFSVAHAADVTVDDLTAEDGTAKFKELVPYNGILNLEGLSRPLLAVQVTKLKDGLAMGLAFNHAVLDGTSTWHFMSSWAEICRG---AQSISTQPFLDR--SKARDTRVKLDLTAPKDPNETSNGEDAANPTVEPPQLVEKIFRFSDFAVHTIKSRANSVIPSDSSKPFSTFQSLTSHIWRHVTLARGLKPEDITIFTVFADCRRRVDPPMPEEYFGNLIQAIFTGTAAGLLAAHGPEFGASVIQKAIAAHDASVIDARNDEWEKSPKIFQF-KDAGVNCVAVGSSPRFRVYEVDFGFGKPETVRSGSNNRFNGMMYLYQGKAGGISIDVEITLEASVMEKLVKSKEFL 448          

Query:   71 LKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDP---------------IINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGW--AAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALE 444
            LK +L   LV FYP+AGRL  R  D      V +DCN   G +F+ A  D AI +     + P +             D  + PLL +Q+T     G  +G  M H + DG S  +F N++S+I     +   I+ PP I R     RDP               +   P   +D  ++       +  IF  T + +  LK++ +A       K SS+  ++  VWR  +  R LP DQ T    A D R RL+PPLP  YFGN I     V   GE+ G D G   AA ++ + ++   D+ +R  LD     P +  L R    F   +I + S  R   +  +FG G+ + +  G    ++G     P  EG GS+ + I L    M   +
Sbjct:   57 LKEALGRALVPFYPMAGRLA-RDEDG----RVEIDCNGE-GVRFVVAETDSAIDEF--GDFAPTMELKKLIPKVEYGDDISAFPLLVLQITHFKCGGTSLGVGMQHHVADGASGLHFINSWSDI----ARGLDIAVPPFIDRSLLRARDPPSPSFPHIEYQPAPSMNTSPAPIQDPTVKSDPTATAVS-IFKLTKQQLDLLKSRVSA-------KYSSYALVAGHVWRCTSIARGLPDDQRTKLYCATDGRARLQPPLPSGYFGNVIFTATPVADAGEITGEDSGLEAAAGRIQRALMRMDDEYLRSALDYLELQPDLSKLVRGAHTFRCPNIGLTSWTRLPIHDADFGWGRPIFMGPG-GIAYEGLAFMLPSSEGDGSLSIAISLQAEHMIKFQ 430          

Query:   71 LKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDI--LSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQL--------------LERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALE 444
            +K +LS  LV FYP+AGRL  R  D      + +DCN + G  F+ A     I D    +PT     +    DH   +    HS PLL +QVT     G  +G  M H   DG S  +F N +S++  A+G   +I  PP I R     RDP    P  H  E+     AP +                 IF  T + +  LKAK+  +   NT   SS++ L+  VWRS+ + R LP DQ T   +A D R RL P LP  YFGN I     +   G+LL     +AA ++H  +V   D  +R  LD     P +  L R    +   ++ + S  R   Y  +FG G+ + +  G    ++G     P     GS+ + I L    M   E
Sbjct:   56 MKEALSKALVPFYPMAGRL-KRDDDG----RIEIDCNGA-GVLFVVADTPSVIDDFGDFAPTLNLRQLIPEVDHSAGI----HSFPLLVLQVTFFKCGGASLGVGMQHHAADGFSGLHFINTWSDM--ARGLDLTI--PPFIDRTLLRARDP--PQPAFHHVEY---QPAPSMKIPLDPSKSGPENTTVSIFKLTRDQLVALKAKSKEDG--NTVSYSSYEMLAGHVWRSVGKARGLPNDQETKLYIATDGRSRLRPQLPPGYFGNVIFTATPLAVAGDLLSKPTWYAAGQIHDFLVRMDDNYLRSALDYLEMQPDLSALVRGAHTYKCPNLGITSWVRLPIYDADFGWGRPIFMGPG-GIPYEGLSFVLPSPTNDGSLSVAIALQSEHMKLFE 427          

Query:   71 LKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDI--LSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPII------------NLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALE 444
            LK +LS  LV FYP+AGRL  R  D      + +DC    G  F+ A  D  + D    +PT     +    D+ + +     S  LL +Q+T     G+ +G  M H   DG S  +F N +S++  A+G   +I  PP I R     RDP               L  T  +  I     P+    IF  T + I  LKAK+  E GN  N  SS++ L+  VWRS    R L  DQ T   +A D R RL P LP  YFGN I     +   G++    + +AA KLH  +    +  +R  LD     P +  L R    F   ++ + S  R   +  +FG G+ + +  G    ++G     P     GS  + I L    M   E
Sbjct:   56 LKEALSKALVPFYPMAGRLC-RDEDG----RIEIDCKGQ-GVLFVEAESDGVVDDFGDFAPTLELRQLIPAVDYSQGI----QSYALLVLQITHFKCGGVSLGVGMQHHAADGASGLHFINTWSDM--ARGLDLTI--PPFIDRTLLRARDPPQPQFPHVEYQPPPTLKVTPENTPISE-AVPETSVSIFKLTRDQINTLKAKSK-EDGNTVN-YSSYEMLAGHVWRSTCMARGLAHDQETKLYIATDGRSRLRPSLPPGYFGNVIFTTTPIAVAGDIQSKPIWYAASKLHDALARMDNDYLRSALDYLELQPDLKALVRGAHTFKCPNLGITSWSRLPIHDADFGWGRPIFMGPG-GIAYEGLSFILPSPTNDGSQSVAISLQAEHMKLFE 429          

Query:   71 LKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMA---ISDILSPTYVPL--VVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFI-GCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDP--IINL-----PFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNT-NKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGH-EGGGSIDLEICLPPHSMTALEADEEFME 451
            +K +LS  LVH+YPLAGRL    T SP   +  VDC    G  F+ A  +     I DI  P    L  +V    D    L       P ++ QVT+   G F+ G  MNH + DG     F N++ ++  A+G    ++ PP   R   + R+P  I NL         +      Y     L R F F  E I +LK +A   + +   N  +SF+ALSA VWR+ T+   +  DQ T    A D R + EP LP+ YFGN I     +   GEL+   L +A   + + +   TD  +R  +D +  +     L       ++++ +  R   +  +FG G+ +   SG     + +V+ +  H E   SI++ + LP  +M   +  E+F++
Sbjct:   85 IKKALSQVLVHYYPLAGRL----TISPEGKLT-VDCTEE-GVVFVEAEANCKMDEIGDITKPDPETLGKLVYDVVDAKNILEI-----PPVTAQVTKFKCGGFVLGLCMNHCMFDGIGAMEFVNSWGQV--ARG--LPLTTPPFSDRTILNARNPPKIENLHQEFEEIEDKSNINSLYTKEPTLYRSFCFDPEKIKKLKLQATENSESLLGNSCTSFEALSAFVWRARTKSLKMLSDQKTKLLFAVDGRAKFEPQLPKGYFGNGIVLTNSICEAGELIEKPLSFAVGLVREAIKMVTDGYMRSAIDYFEVTRARPSLSS-----TLLITTWSRLGFHTTDFGWGEPIL--SGPVALPEKEVTLFLSHGEQRRSINVLLGLPATAMDVFQ--EQFLQ 456          

Query:   29 LTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDI--LSPTYVPLVVQSFFDHDRALNHDG--HSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKR---WFPDGRDPIINLPFTHRDEFIRR----YEAPQLLER-------IFHFTGESIARLKAKANAEAGNNTNK-ISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVR---EWLDA---WWKSPFMYHLDRLFDPF----SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALE 444
            L  WD V  ++ +I     + KP+          F   +++ LK SLS  LVHFYP+AGRL        P     ++CN + G +FI A  +  +SD    SPT        F +    +N+     + PL   QVT+    GI +  +++H + DG S  +  + +  + + +     +   P + R   W  +   P ++ P     EF +      E   + ER       +   +   + +L++KAN    ++  K  + ++ ++  VWR   + R   P+Q T   +  D R R+EPPLPR YFGN+   +   +T GEL+ ++LG+AA  + + + N T++ V    E+L       K   ++ L     PF    ++ + S      YG +FG G+      G  H FDG     P     GS+ L  CL    M A +
Sbjct:   25 LAEWDQVG-TITHIPTLYFYDKPS--------ESFQGNVVEILKTSLSRVLVHFYPMAGRLRWL-----PRGRFELNCN-AEGVEFIEAESEGKLSDFKDFSPT------PEFENLMPQVNYKNPIETIPLFLAQVTKFKCGGISLSVNVSHAIVDGQSALHLISEWGRLARGE----PLETVPFLDRKILWAGEPLPPFVSPPKFDHKEFDQPPFLIGETDNVEERKKKTIVVMLPLSTSQLQKLRSKANGSKHSDPAKGFTRYETVTGHVWRCACKARGHSPEQPTALGICIDTRSRMEPPLPRGYFGNATLDVVAASTSGELISNELGFAASLISKAIKNVTNEYVMIGIEYLKNQKDLKKFQDLHALGSTEGPFYGNPNLGVVSWLTLPMYGLDFGWGKEFYTGPG-THDFDGDSLILPDQNEDGSVILATCLQVAHMEAFK 444          

Query:   69 DRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLER-----------------IFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSM 440
            +R++ +L+  LV FYP+AGRL  R  D      V +DC+   G  F+ A    A  D     + P +           + D  S PLL +QVT     G+ +G  M H + DG S  +F N++S++ +     A I+  P I R     RDP     +TH    +    AP +L                   IF  T   + RL+A+     G    + S++  L+A VWR ++  R LP +Q T    A D R RL+PPLP  YFGN I     +   G++ G     AA  +   +   +D   R  LD     P +  L R    F   ++ + S  R   +  +FG G+ V +  G    ++G     P     GS+ + I L    M
Sbjct:   63 ERMRRALAEALVPFYPMAGRL-ARDEDG----RVEIDCSGE-GVLFVEARAPGAAVDDYG-DFAPTMELKRLIPAVDYSGDISSFPLLVLQVTYFKCGGVSLGVGMQHHVADGMSGLHFINSWSDLCRG----AQIAVMPFIDRTLLRARDPPTP-SYTH----VEYQPAPAMLSSAPQALTGKPTLAPTAVDIFKLTRSELGRLRAQL--PTGEGAPRFSTYAVLAAHVWRCVSLARGLPAEQPTKLYCATDGRHRLQPPLPEGYFGNVIFTATPLAEAGKVTGAVADGAA-VIQGALDRMSDDYCRSALDYLETQPDLSALVRGAHTFRCPNLGLTSWVRLPIHDADFGWGRPVFMGPG-GIAYEGLAFVLPSANKDGSLSIAISLQAEHM 435          

Query:   69 DRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASL-DMAISDI--LSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTEL-VDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPII-------------NLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPF---SIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSM 440
            +R++ +L+  LV FYP+AGRL  R  D      V +DCN   G  F+ A   D ++ D    +PT     +    D+      D  S  LL +QVT     G+ +G  M H + DG S  +F N++S++ +       I+  P I R     RDP                L    +     +   P     IF  T   + RL+++    +G    + S++  L+A VWR ++  R LP +Q T    A D R RL+PPLP  YFGN I     +   G++    L   A  + + +    D   R  LD     P +  L R    F   ++ + S  R   +  +FG G+ V +  G    ++G     P     GS+ + I L    M
Sbjct:   59 ERMRRALAEALVPFYPMAGRL-ARDEDG----RVEIDCNGE-GVLFVEADAPDASVDDYGDFAPTMELKRLIPAVDY----TDDISSFSLLVLQVTYFKCGGVSLGVGMQHHVADGMSGLHFINSWSDLCRG----TQIAIMPFIDRTLLRARDPPTPSYPHVEYQPAPAMLSSVPQSVTANKTTPPPTAVDIFKLTRSDLGRLRSQL--PSGEGAPRFSTYAVLAAHVWRCVSLARGLPSEQPTKLYCATDGRQRLQPPLPEGYFGNVIFTATPLAEAGKVTS-GLADGAAVIQEALDRMNDSYCRSALDYLELQPDLSALVRGAHTFRCPNLGLTSWVRLPIHDADFGWGRPVFMGPG-GIAYEGLAFVLPSANKDGSLSIAISLQAEHM 432          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATSC 455
            MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKM SISRPPV+KRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITR RNLPPDQTT CRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME TSC
Sbjct:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMDSISRPPVVKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRTRNLPPDQTTSCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEVTSC 455          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATSC 455
            MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPAS DQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTT CRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYG+EFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME TSC
Sbjct:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASGDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTSCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGSEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEVTSC 455          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATSC 455
            MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPAS DQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPV+KRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTT CRMAADNRPRLEPPLPREYFGNSINPLRGV+             AWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYG+EFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFME TSC
Sbjct:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASGDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVVKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTSCRMAADNRPRLEPPLPREYFGNSINPLRGVS------------HAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGSEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEVTSC 443          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGK-MASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            MN   VQ +SECFV+P+  +EE KQPCYLTPWDL ML+VQYIQKGLLF+KP   PA+  Q DFI TLLD+LK SLSLTLVHFYPLAGRL T + ++PP+Y VFVDCNNSPGAKFIHA LDM ISDILSPTYVPLVVQS FDHDRALN DGH+RPLLSIQVTELVDG+FIGCSMNH LGDGTS+WNF NA+SEIFQAQ K   SIS PP+I+RWF DG  P+INLP  H++EF+ RYEAP L ER+FHF+ ESIA++K KANAE   NT++ISSFQ+LSALVWRSITR R+LP DQ T CR+A +NR RL PPLP  YFGN +  +RGVTTVG+LL H LGWAAWKLH+ VV  TDK VR +++AW +SP +Y L + FDP S+MMGSSPRFN YGNEFGLG+A+ALRSGYAHKFDGKVS+YPGHEGGGSIDLE+CL P +MTALE+D EFM A S
Sbjct:    1 MNPSIVQQISECFVKPQLTTEESKQPCYLTPWDLAMLAVQYIQKGLLFKKP---PATHSQQDFINTLLDKLKQSLSLTLVHFYPLAGRLATVKNENPPAYSVFVDCNNSPGAKFIHAVLDMTISDILSPTYVPLVVQSLFDHDRALNIDGHTRPLLSIQVTELVDGVFIGCSMNHSLGDGTSYWNFLNAWSEIFQAQEKGTLSISYPPIIQRWFLDGHGPMINLPLKHQEEFMNRYEAPPLKERVFHFSLESIAKVKVKANAEV--NTSEISSFQSLSALVWRSITRARHLPHDQVTSCRLAINNRSRLAPPLPENYFGNCVQTVRGVTTVGQLLEHSLGWAAWKLHEAVVGHTDKEVRGFVEAWLQSPSLYQLHQFFDPQSVMMGSSPRFNMYGNEFGLGKAIALRSGYAHKFDGKVSSYPGHEGGGSIDLEVCLSPDNMTALESDVEFMNAVS 450          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            MN P V+ +SECFV+P + SEE KQP YLT WDL MLSVQYIQKGLLF KP  PP + ++ D IK +LDRL+ SLSLTLVHFYPLAGRL TR+ ++P SY VFVDCNNS GAK IHA++DM++SDILSPTYVPLVVQSFFDHDRA+NHDGH+ PLLS+QVTELVDG+FIGCSMNH LGDG+SFW+FFN  SEIFQAQG    ISRPPV++RWFP+G  P+++LPF+H+DEFI R+E+PQLLERIFHF+ ESIA++KA+AN+E   NT KISSFQ+LSA VWRS+T+ R+ P DQ TGCR+A +NR RLEPPL  +YFGNSI  +R VTT GELL  +LGWAAW+LHQ VVN TDK+VR +++ W  SPF+Y + +LFDP SIMMGSSPRFNKYGNEFGLG+A+ LRSGYAHKFDGKVS+YPG EGGGSIDLE+CLP HSM ALE+DEEFM A S
Sbjct:    1 MNPPTVRCISECFVKPHHVSEESKQPFYLTTWDLSMLSVQYIQKGLLFAKP--PPENCEE-DLIKNMLDRLRKSLSLTLVHFYPLAGRLATRREENPTSYFVFVDCNNSRGAKLIHAAVDMSVSDILSPTYVPLVVQSFFDHDRAINHDGHTSPLLSVQVTELVDGVFIGCSMNHALGDGSSFWHFFNTLSEIFQAQGDNIKISRPPVLERWFPEGHGPLLSLPFSHQDEFISRFESPQLLERIFHFSAESIAKIKARANSEY--NTRKISSFQSLSAFVWRSLTKARHFPSDQLTGCRLAINNRSRLEPPLSPDYFGNSIQTVRAVTTAGELLEQNLGWAAWQLHQAVVNHTDKSVRGFVNDWLCSPFIYQIAQLFDPQSIMMGSSPRFNKYGNEFGLGKALTLRSGYAHKFDGKVSSYPGREGGGSIDLEVCLPAHSMHALESDEEFMAAVS 449          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            MN P  + +SECFV+P + S+E KQP YLT WDL MLSVQYIQKGLLF KP  PP    Q D IK +LDRLK SLSL+LVHFYPLAGRL TR+ ++PP+Y VFVDCNNSPGAKFIHA++D  +S ILSPTYVPLVVQSFFDHDRA+NHDGH+RPLLSIQVTELVDG+FIGCSMNH LGDG +FW+FFN  SEIFQAQG    ISR PV+KRWFP+G  P+INLPFTH+DEFI R+EAPQLLERIFHF+ ESIA+LKA+AN+E   NT+KISSFQ+LSA VW SIT+ R  P DQ T CR+A +NR RL+PPL  +YFGNSI  +R VTT GELL  +LGWAAW+LH  VVN TDK+VR +++ W +SPF+Y L + FDP S+MMGSSPRFNKYGNEFGLG+A+ALRSGYAHKFDGKVS+YPG EGGGSIDLE+CLP HSM ALE+DEEFM A S
Sbjct:    1 MNPPKARCISECFVKPPHVSQESKQPFYLTTWDLAMLSVQYIQKGLLFPKP--PPEDCQQ-DLIKNILDRLKKSLSLSLVHFYPLAGRLATRREENPPAYSVFVDCNNSPGAKFIHAAVDTTVSHILSPTYVPLVVQSFFDHDRAINHDGHTRPLLSIQVTELVDGVFIGCSMNHALGDGATFWHFFNTLSEIFQAQGDNVKISRQPVLKRWFPEGHGPLINLPFTHQDEFIGRFEAPQLLERIFHFSAESIAKLKARANSEY--NTSKISSFQSLSAFVWMSITKARRFPNDQVTSCRLAINNRSRLDPPLSPDYFGNSIQTVRAVTTAGELLEQNLGWAAWQLHLAVVNHTDKSVRGFVNDWLRSPFIYQLGQFFDPQSVMMGSSPRFNKYGNEFGLGKALALRSGYAHKFDGKVSSYPGREGGGSIDLEVCLPAHSMNALESDEEFMAAVS 449          

Query:    2 NSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            N P ++++S+CF++P+Y  E+ KQP YL+PWDL MLSV YIQKGLLF KP    A+ +Q DFIKTLLD+LKHSLSLTLVHFYPLAGR VT + ++PPS ++FVDC NSPGAKFIHA+LDM ISDILSPT VPL+ QSFFDHDRALN+DGH+RPLLSIQVTEL DGIFIGCS+NH + DGTS+W+FFNA+SE+FQAQG   S++RPP+ KRWFPDG DPI+NLPFTH+DEF+ R+EAP+L ER FHF+ ESIA+LKAKANAE+  NTNKISSFQ+LSAL+WR ITR R LP DQ T CR+A +NR R+EPPL  +YFGNSI    GVTT GELL H LGWAAWKLH+ V NQTDK VR+W+D+W +SPF+Y L R FDP+SIMMGSSPRFN YGNEFG+G+A+ALRSGYAHKFDGKVSA+PG+E  GSIDLE+CL P SM A+E+DEEFM+A S
Sbjct:    3 NPPQIRFISDCFIKPQYALEDSKQPLYLSPWDLAMLSVHYIQKGLLFTKPQ---AAYEQKDFIKTLLDKLKHSLSLTLVHFYPLAGRFVTHKNENPPSSLIFVDCMNSPGAKFIHATLDMTISDILSPTDVPLITQSFFDHDRALNYDGHTRPLLSIQVTELKDGIFIGCSINHCIVDGTSYWHFFNAWSEVFQAQGNDISMTRPPIHKRWFPDGVDPILNLPFTHQDEFLSRFEAPKLRERFFHFSSESIAKLKAKANAES--NTNKISSFQSLSALLWRCITRARCLPHDQVTSCRLAINNRSRMEPPLSNDYFGNSIAAKGGVTTAGELLEHSLGWAAWKLHEAVANQTDKVVRDWIDSWLQSPFIYQLARDFDPYSIMMGSSPRFNMYGNEFGMGKALALRSGYAHKFDGKVSAFPGYE-EGSIDLEVCLLPDSMRAIESDEEFMDAVS 449          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASI--SRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            M +P V+ +SECF++P++ SEE  +PCYLTPWDL MLSV YIQKGLLF KP   P   D  +F+ TLLD+LK SL+LTL HFYPLAGRL T++ DS PSYVVFVDCNNSPG KFIHA+ DM ISDILSP YVP V+QSFFDHDR +NHDG +  LLSIQ+TELVDGIFIGCS+NH + DGTSFW+FFNA+SE+F AQGK +SI  SRPP++KRWFPDG  PIINLPFTH DEFI R+EAP L ERIFHF+ ESIA+LKAKANA+   N+NKISSFQALSALVWRSITR R  P +Q T CR+A  NR RL+PPLP  YFGNSI  +RG+ T GELL HDLGWAAW LHQ VV  TDKAVR WL++W++S F+Y L   FDP S+MMGSSPRFNKYG EFGLG+ +A+RSGYAHKFDGKVS YPG EGGGSIDLE+CLPP+SM+ALE+++EFMEA S
Sbjct:   80 MATPTVRLISECFIKPKFTSEETNEPCYLTPWDLAMLSVNYIQKGLLFSKP---PDVDDPQNFMATLLDKLKDSLALTLDHFYPLAGRLATKKEDSSPSYVVFVDCNNSPGLKFIHAAADMTISDILSPIYVPQVIQSFFDHDRVINHDGRTLSLLSIQITELVDGIFIGCSINHSMVDGTSFWHFFNAWSEVFTAQGKNSSITLSRPPILKRWFPDGYGPIINLPFTHHDEFISRFEAPVLRERIFHFSSESIAKLKAKANAQC--NSNKISSFQALSALVWRSITRARCFPHEQVTSCRLATGNRTRLDPPLPENYFGNSIQTVRGIATAGELLEHDLGWAAWLLHQAVVGHTDKAVRGWLESWFQSHFIYQLGLFFDPNSVMMGSSPRFNKYGIEFGLGKGLAVRSGYAHKFDGKVSCYPGREGGGSIDLEVCLPPNSMSALESNQEFMEAVS 530          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMASISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            MN   V+ +SECFV+P + S+E KQP YLT WDL MLSVQYIQKGLLF KP  PP    Q D IK +LDRLK SLSL+LVHFYPLAGRL TR+ ++PP+Y VFVDCNNSPGAKFIHA++D  +S ILSPTYVPLVVQSFFDHDRA+NHDGH+RPLLSIQVTELVDG+FIGCSMNH +GDG++FW+FFN  SEIFQAQG    ISR PV+KRWFP+G  P+INLPFTH+DE IRR+EAPQLLERIFHF+ ESIA+LKA+AN+E   NT+KISSFQ+LSA VW SIT+ R  P DQ T CR+A +NR RL+PPL  +YFGNSI  +R VTT GEL+  +LGWAAW+LH  VVN TDK+VR +++ W +SPF+Y L + FDP S+MMGSSPRFNKYGNEFGLG+A+ALRSGYAHKFDGKVS+YPG EGGGSIDLE+CLP HSM ALE+D EFM A S
Sbjct:    1 MNPSKVRCISECFVKPPHVSQESKQPFYLTTWDLAMLSVQYIQKGLLFAKP--PPEDCPQ-DLIKNILDRLKKSLSLSLVHFYPLAGRLATRREENPPAYFVFVDCNNSPGAKFIHAAVDATVSHILSPTYVPLVVQSFFDHDRAINHDGHTRPLLSIQVTELVDGVFIGCSMNHAIGDGSTFWHFFNILSEIFQAQGDNVKISRQPVLKRWFPEGHGPLINLPFTHQDELIRRFEAPQLLERIFHFSAESIAKLKARANSEY--NTSKISSFQSLSAFVWMSITKARRFPNDQLTSCRLAINNRSRLDPPLSPDYFGNSIQTVRAVTTAGELVEQNLGWAAWQLHLAVVNHTDKSVRGFVNDWLRSPFIYQLGQFFDPQSVMMGSSPRFNKYGNEFGLGKALALRSGYAHKFDGKVSSYPGREGGGSIDLEVCLPAHSMNALESDAEFMAAVS 449          

Query:    1 MNSPAVQYMSECFVQPEYFSEEMKQPCYLTPWDLVMLSVQYIQKGLLFRKPAIPPASVDQVDFIKTLLDRLKHSLSLTLVHFYPLAGRLVTRQTDSPPSYVVFVDCNNSPGAKFIHASLDMAISDILSPTYVPLVVQSFFDHDRALNHDGHSRPLLSIQVTELVDGIFIGCSMNHVLGDGTSFWNFFNAFSEIFQAQGKMAS---ISRPPVIKRWFPDGRDPIINLPFTHRDEFIRRYEAPQLLERIFHFTGESIARLKAKANAEAGNNTNKISSFQALSALVWRSITRIRNLPPDQTTGCRMAADNRPRLEPPLPREYFGNSINPLRGVTTVGELLGHDLGWAAWKLHQTVVNQTDKAVREWLDAWWKSPFMYHLDRLFDPFSIMMGSSPRFNKYGNEFGLGQAVALRSGYAHKFDGKVSAYPGHEGGGSIDLEICLPPHSMTALEADEEFMEATS 454
            MN   V+++SE FV+P+Y SEEMKQP YLTPWDL MLSV YIQKGLL+ KPA+     DQ +FI TLLDRLK SLSLTLVHFYPLAGR  T +++   S +VFVD N+SPGAK IHASLD+ +SDI+SPTYVPLVVQS FDHDRA+NHDGH+ PL++IQVT+L DGIFIGCSMNHVLGDGTS+WNFF A+SE FQA G  ++   +SRPP++KRWFPDG DPIINLPFTH++EF+ RYEAP+LLER FHFT ES+A+LKA+AN+E+   T+KISSFQALSALVWRSI+R R  P DQ T  ++A DNR RL+PPL ++YFGNSI  +RGV T GELL HDLGWAAWKLH+ VVN  DK VRE+L++W +SP +Y L + F P ++M+GSSPRFNKYG EFGLG+AV LRSGYAHKFDGKVS+YPGHEGGGS+DLE+CLPP SM ALE+DEEFM A S
Sbjct:    1 MNPKTVKHISEFFVKPQYVSEEMKQPIYLTPWDLAMLSVHYIQKGLLYTKPAVD----DQEEFINTLLDRLKQSLSLTLVHFYPLAGRFKTVKSEDTKSCLVFVDLNDSPGAKLIHASLDLTVSDIVSPTYVPLVVQSLFDHDRAINHDGHTSPLVTIQVTDLADGIFIGCSMNHVLGDGTSYWNFFQAYSETFQALGSSSTTSMVSRPPIVKRWFPDGHDPIINLPFTHQEEFLSRYEAPELLERYFHFTAESVAKLKARANSES--KTSKISSFQALSALVWRSISRARRFPNDQMTSTKLATDNRLRLKPPLSQDYFGNSIQTVRGVATAGELLEHDLGWAAWKLHEAVVNHNDKTVREFLESWRQSPMIYQLGQFFLPENVMIGSSPRFNKYGIEFGLGKAVTLRSGYAHKFDGKVSSYPGHEGGGSVDLEVCLPPQSMHALESDEEFMSAAS 451